33073-64-2

Basic information

• Product Name: ethyl 3-aminocyclohexanecarboxylate
• CAS NO: 33073-64-2
• Molecular Formula: C₉H₁₇NO₂
• Molecular Weight: 171.2368
• Mol File: 33073-64-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 235.3°C at 760 mmHg
• Flash Point: 101.5°C
• Density: 1.018g/cm³
• Vapor Pressure: 0.0505mmHg at 25°C
• Refractive Index: 1.468
• CAS DataBase Reference: ethyl 3-aminocyclohexanecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-aminocyclohexanecarboxylate(33073-64-2)
• EPA Substance Registry System: ethyl 3-aminocyclohexanecarboxylate(33073-64-2)

Safety Data

• Hazardous Substances Data: 33073-64-2(Hazardous Substances Data)

Upstream product

• 227783-08-6 (1S,3R)-3-ethoxycarbonylcyclohexane-1-carboxylic acid 
• 62059-56-7 cis-1,3-Cyclohexanedicarboxylic acid diethyl ester 
• 4355-31-1 3-oxabicyclo<3.3.1>nonane-2,4-dione 
• 2305-30-8 (1R)-cyclohexane-1,3-dicarboxylic acid 

Downstream Products

• 1259279-62-3 N-[(1R,3S)-3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]-pyridin-3-yl)pyrimidin-4-yl]amino]cyclohexyl]morpholine-4-carboxamide 

Relevant articles and documents

Development of a Scalable Synthesis of an Azaindolyl-Pyrimidine Inhibitor of Influenza Virus Replication

A scalable, asymmetric route for the synthesis of the influenza virus replication inhibitor 2 is presented. The key steps include an enzymatic desymmetrization of cis-1,3-cyclohexanediester in 99% yield and 96% ee, SNAr displacement of a methanesulfinylpyrimidine, and a Curtius rearrangement to form a morpholinyl urea. This high-yielding route allowed us to rapidly synthesize hundreds of grams of 2 in 99% purity to support in vivo studies.

Spiro-subsituted glutaramide diuretic agents

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