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372117-76-5

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  • High quality Ethyl 4-(3-chloro-4-methoxybenzylamino)-2-(methylsulfonyl)pyrimidine-5-carboxylate supplier in China

    Cas No: 372117-76-5

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  • 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-(methylthio)-5-Pyrimidinecarboxylic acid ethyl ester

    Cas No: 372117-76-5

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372117-76-5 Usage

General Description

Ethyl 4-(3-chloro-4-methoxybenzylamino)-2-(methylsulfonyl)pyrimidine-5-carboxylate is a complex chemical compound with several functional groups, including an ethyl ester, an amino group, a sulfonyl group, and a carboxylic acid group. It is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs, particularly those that target specific enzymes or receptors in the body. The compound's structure suggests that it may have potential therapeutic applications, possibly as an inhibitor or modulator of biological pathways. Its synthesis and manipulation require expertise in organic chemistry, and it is typically handled in controlled laboratory settings due to its complexity and potential biological activity.

Check Digit Verification of cas no

The CAS Registry Mumber 372117-76-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,2,1,1 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 372117-76:
(8*3)+(7*7)+(6*2)+(5*1)+(4*1)+(3*7)+(2*7)+(1*6)=135
135 % 10 = 5
So 372117-76-5 is a valid CAS Registry Number.

372117-76-5Relevant articles and documents

Preparation method of pharmaceutical compound avanafil

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Paragraph 0014; 0043; 0050; 0053; 0054, (2019/02/10)

The invention discloses a preparation method of a pharmaceutical compound avanafil, and belongs to the technical field of synthesis of pharmaceutical compounds. The key point of the technical scheme of the invention is as follows: a synthesis route of the synthetic method of the pharmaceutical compound avanafil is shown in the specification. The synthetic method has the advantages that the yield is high, the cost is low, the method is economical and environmentally friendly and is suitable for industrialization, the product purity is high and the like, and the method is a synthetic method withindustrial production values.

The discovery of avanafil for the treatment of erectile dysfunction: A novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor

Sakamoto, Toshiaki,Koga, Yuichi,Hikota, Masataka,Matsuki, Kenji,Murakami, Michino,Kikkawa, Kohei,Fujishige, Kotomi,Kotera, Jun,Omori, Kenji,Morimoto, Hiroshi,Yamada, Koichiro

, p. 5460 - 5465 (2015/01/08)

Novel pyrimidine-5-carboxamide derivatives bearing a 3-chloro-4-methoxybenzylamino group at the 4-position were identified as potent and highly selective phosphodiesterase 5 inhibitors. Among them, we successfully found 10j (avanafil) which exhibited a potent relaxant effect on isolated rabbit cavernosum (EC30 = 2.1 nM) and a high isozyme selectivity.

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