330792-81-9

Basic information

• Product Name: 3-(4-amino-3-methoxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
• Synonyms: 3-(4-amino-3-methoxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
• CAS NO: 330792-81-9
• Molecular Weight: 436.56
• Mol File: 330792-81-9.mol

Chemical Properties

• CAS DataBase Reference: 3-(4-amino-3-methoxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-amino-3-methoxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine(330792-81-9)
• EPA Substance Registry System: 3-(4-amino-3-methoxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine(330792-81-9)

Safety Data

• Hazardous Substances Data: 330792-81-9(Hazardous Substances Data)

Upstream product

• 330792-74-0 3-iodo-1-((trans)-4-(4-methylpiperazin-1-yl)cyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 330792-61-5 3-iodo-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 330792-72-8 4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexan-1-one 
• 2380-63-4 4-Aminopyrazolo<3,4-d>pyrimidin 
• 330793-47-0 (4-{4-amino-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxy-phenyl)-carbamic acid tert-butyl ester 
• 151266-23-8 4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine 

Relevant articles and documents

Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck -- a selectivity insight.

A series of para-substituted 3-phenyl pyrazolopyrimidines was synthesized and evaluated as inhibitors of lck. The nature of the substitution affected enzyme selectivity and potency for lck, src, kdr, and tie-2. The para-phenoxyphenyl analogue 2 is an orally active lck inhibitor with a bioavailability of 69% and exhibits an extended duration of action in animal models of T cell inhibition.