330796-62-8

Basic information

• Product Name: 5(S)-HETE-D8
• Synonyms: 5(S)-HETE-D8;5S-HYDROXY-6E,8Z,11Z,14Z-EICOSATETRAENOIC-5,6,8,9,11,12,14,15-D8 ACID
• CAS NO: 330796-62-8
• Molecular Formula: C20H24D8O3
• Molecular Weight: 328.52
• Mol File: 330796-62-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5(S)-HETE-D8(CAS DataBase Reference)
• NIST Chemistry Reference: 5(S)-HETE-D8(330796-62-8)
• EPA Substance Registry System: 5(S)-HETE-D8(330796-62-8)

Safety Data

• Hazardous Substances Data: 330796-62-8(Hazardous Substances Data)

Usage

Description

5(S)-HETE-D8, also known as 5-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid-d8, is a deuterated analog of 5(S)-HETE, a eicosanoid derived from arachidonic acid. It contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. 5(S)-HETE-D8 is characterized by its unique structure and properties, making it a valuable tool in various research and analytical applications.

Uses

Used in Analytical Chemistry:
5(S)-HETE-D8 is used as an internal standard for the quantification of 5(S)-HETE by gas chromatography (GC) or liquid chromatography (LC) coupled with mass spectrometry (MS). The incorporation of deuterium atoms in 5(S)-HETE-D8 allows for accurate measurement and quantification of the native 5(S)-HETE in biological samples, which is essential for understanding its role in various biological processes.
Used in Pharmaceutical Research:
5(S)-HETE-D8 serves as a valuable research tool in the development of drugs targeting the 5-lipoxygenase pathway. By providing a stable and easily detectable analog of 5(S)-HETE, researchers can better understand the mechanisms of action and potential therapeutic applications of compounds that modulate this pathway.
Used in Cell Biology:
5(S)-HETE has been shown to have proliferative and chemotactic effects on granulocytes, making 5(S)-HETE-D8 a useful tool for studying the behavior and function of these immune cells. Additionally, when 5(S)-HETE is further metabolized to 5-oxoETE, it becomes a more potent eosinophil chemoattractant than leukotriene B4. This property of 5(S)-HETE-D8 can be utilized to investigate the migration and activation of eosinophils in various immune responses.