330803-45-7Relevant academic research and scientific papers
Inhibitors of factor Xa
-
, (2008/06/13)
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Design, synthesis and biological activity of novel non-amidine factor Xa inhibitors. Part 1: P1 structure-activity relationships of the substituted 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides
Jia, Zhaozhong J.,Wu, Yanhong,Huang, Wenrong,Goldman, Erick,Zhang, Penglie,Woolfrey, John,Wong, Paul,Huang, Brian,Sinha, Uma,Park, Gary,Reed, Andrea,Scarborough, Robert M.,Zhu, Bing-Yan
, p. 1651 - 1655 (2007/10/03)
Based on DuPont Pharmaceuticals' monobenzamidine lead structure SN429, we have designed the biphenyl 1-(2-naphthyl)-1H-pyrazole-5-carboxylamides as a novel series of non-basic factor Xa inhibitors. We have discovered that the displacement of the benzamidine moiety with substituted 2-naphthyl structures not only results in highly potent factor Xa inhibitors, but also significantly increases their enzyme specificity and oral bioavailability.
Inhibitors of factor Xa
-
, (2008/06/13)
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
