330834-06-5Relevant academic research and scientific papers
Structural Insights into Notum Covalent Inhibition
Zhao, Yuguang,Svensson, Fredrik,Steadman, David,Frew, Sarah,Monaghan, Amy,Bictash, Magda,Moreira, Tiago,Chalk, Rod,Lu, Weixian,Fish, Paul V.,Jones, E. Yvonne
, p. 11354 - 11363 (2021)
The carboxylesterase Notum hydrolyzes a palmitoleate moiety from Wingless/Integrated(Wnt) ligands and deactivates Wnt signaling. Notum inhibitors can restore Wnt signaling which may be of therapeutic benefit for pathologies such as osteoporosis and Alzhei
