314284-83-8Relevant academic research and scientific papers
Structural Insights into Notum Covalent Inhibition
Zhao, Yuguang,Svensson, Fredrik,Steadman, David,Frew, Sarah,Monaghan, Amy,Bictash, Magda,Moreira, Tiago,Chalk, Rod,Lu, Weixian,Fish, Paul V.,Jones, E. Yvonne
supporting information, p. 11354 - 11363 (2021/08/16)
The carboxylesterase Notum hydrolyzes a palmitoleate moiety from Wingless/Integrated(Wnt) ligands and deactivates Wnt signaling. Notum inhibitors can restore Wnt signaling which may be of therapeutic benefit for pathologies such as osteoporosis and Alzhei
INDOLINE SCAFFOLD SHP-2 INHIBITORS AND CANCER TREATMENT METHOD
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Page/Page column 46-47, (2010/04/03)
The subject invention concerns methods and compounds for inhibiting Shp2. In one embodiment, a compound of the invention has a chemical structure as shown in formula I or II: wherein X, Y, and Z are independently N or S; R1 is cycloalkyl, heter
