3309-52-2

Basic information

• Product Name: Cho-Pro-OH
• Synonyms: Cho-Pro-OH
• CAS NO: 3309-52-2
• Molecular Weight: 241.287
• Mol File: 3309-52-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Cho-Pro-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Cho-Pro-OH(3309-52-2)
• EPA Substance Registry System: Cho-Pro-OH(3309-52-2)

Safety Data

• Hazardous Substances Data: 3309-52-2(Hazardous Substances Data)

Upstream product

• 147-85-3 L-proline 
• 13248-54-9 cyclohexyl chloroformate 

Downstream Products

• 1422467-59-1 (S)-cyclohexyl 2-(((6-methylpyridin-2-yl)methyl)carbamoyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Cyclohexyloxycarbonyl based orthogonal solid phase peptide synthesis in Boc chemistry

Application of N-cyclohexyloxocarbonyl (Choc) protection in Boc chemistry on solid phase provides a new possibility for the preparation of protected peptide fragments. A Choc/OcHex protection scheme allows also the assembly of cyclic lactam peptides linked to the resin through the C- terminus. Choc protection is stable under the 1M TMSOTf-thioanisole/TFA cleavage condition at 0°C, but it is removable by anhydrous HF. We have utilized cyclohexyloxycarbonyl as an orthogonal protecting group for the synthesis of a i) bicyclic epitope peptide of glycoprotein D of HSV 1 on BHA resin and ii) fully protected hexapeptide involved in protein transport on Merrifield resin.