330935-02-9Relevant academic research and scientific papers
Synthesis of Stannylated Aryl Imines and Amines via Aryne Insertion Reactions into Sn?N Bonds
Kran, Eva,Mück-Lichtenfeld, Christian,Daniliuc, Constantin G.,Studer, Armido
, p. 9281 - 9285 (2021/05/31)
The reaction of in situ generated arynes with stannylated imines to provide ortho-stannyl-aniline derivatives is reported. The readily prepared trimethylstannyl benzophenone imine is introduced as an efficient reagent to realize the aryne σ-insertion reaction. The imine functionality is an established N-protecting group and insertions proceed with good yields and good to excellent regioselectivities. The product anilines are valuable starting materials for follow-up chemistry thanks to the rich chemistry offered by the trimethylstannyl moiety.
Design, synthesis, and structure - Activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids
Michellys, Pierre-Yves,Ardecky, Robert J.,Chen, Jyun-Hung,D'Arrigo, Jennifer,Grese, Timothy A.,Karanewsky, Donald S.,Leibowitz, Mark D.,Liu, Sha,Mais, Dale A.,Mapes, Christopher M.,Montrose-Rafizadeh, Chahrzad,Ogilvie, Katheen M.,Reifel-Miller, Anne,Rungta, Deepa,Thompson, Anthony W.,Tyhonas, John S.,Boehm, Marcus F.
, p. 4087 - 4103 (2007/10/03)
Retinoid X receptor:peroxisome proliferative-activated receptor (RXR:PPAR) heterodimers play a critical role in the regulation of glucose (RXR/PPARγ) and lipid metabolism (RXR/PPARα). Previously, we described a concise structure-activity relationship stud
