331-19-1

Basic information

• Product Name: Diazene, (3-fluorophenyl)phenyl-
• CAS NO: 331-19-1
• Molecular Formula: C12H9FN2
• Molecular Weight: 200.215
• Mol File: 331-19-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Diazene, (3-fluorophenyl)phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Diazene, (3-fluorophenyl)phenyl-(331-19-1)
• EPA Substance Registry System: Diazene, (3-fluorophenyl)phenyl-(331-19-1)

Safety Data

• Hazardous Substances Data: 331-19-1(Hazardous Substances Data)

Upstream product

• 372-19-0 meta-fluoroaniline 
• 586-96-9 Nitrosobenzene 

Downstream Products

• 50797-39-2 Mn(N₂C₁₂H₈F)(CO)4 
• 50797-38-1 Mn(N₂C₁₂H₈F)(CO)4 
• 50770-99-5 Pd(N₂C₁₂H₈F)(C₅H₅) 
• 50770-97-3 Pd(N₂C₁₂H₈F)(C₅H₅) 
• 50770-98-4 Pd(N₂C₁₂H₈F)(C₅H₅) 

Relevant articles and documents

Photosensitive and Photoswitchable TRPA1 Agonists Optically Control Pain through Channel Desensitization

Transient receptor potential ankyrin 1 (TRPA1) channel, as a nonselective ligand-gated cation channel robustly in dorsal root ganglion sensory neurons, is implicated in sensing noxious stimuli and nociceptive signaling. However, small-molecule tools targeting TRPA1 lack temporal and spatial resolution, limiting their use for validation of TRPA1 as a therapeutic target for pain. In our previous work, we found that 4,4′-(diazene-1,2-diyl)dianiline (AB1) is a photoswitchable TRPA1 agonist, but the poor water solubility and activity hinder its further development. Here, we report a series of specific and potent azobenzene-derived photoswitchable TRPA1 agonists (series 1 and 2) that enable optical control of the TRPA1 channel. Two representative compounds 1g and 2c can alleviate capsaicin-induced pain in the cheek model of mice through channel desensitization but not in TRPA1 knockout mice. Taken together, our findings demonstrate that photoswitchable TRPA1 agonists can be used as pharmacological tools for study of pain signaling.