331002-15-4

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 22706-11-2 3-phenyl-4-amino-5-mercapto-1,2,4-triazole 
• 38539-87-6 potassium 3-benzoyldithiocarbazinate 
• 613-94-5 benzoic acid hydrazide 
• 93-89-0 benzoic acid ethyl ester 

Downstream Products

• 1269527-28-7 6-{[4-(4-bromobenzylideneamino)-5-phenyl-4H-1,2,4-triazol-3-ylthio]methyl}-N₂-o-tolyl-1,3,5-triazine-2,4-diamine 
• 1269527-27-6 6-{[4-(4-bromobenzylideneamino)-5-phenyl-4H-1,2,4-triazol-3-ylthio]methyl}-N₂-(4-methoxyphenyl)-1,3,5-triazine-2,4-diamine 

Relevant academic research and scientific papers

Studies on Absorption and Emission Characteristics of Inclusion Complexes of Some 4-Arylidenamino-5-phenyl-4H-1, 2, 4-triazole-3-thiols

The inclusion complexes of a series of 4-arylidenamino-5-phenyl-4H-1, 2, 4-triazole-3-thiols have been prepared with β-cyclodextrin. The compounds and their inclusion complexes have been characterized by studying their physical and spectral properties. Th

Impact of inclusion complex formation on antibacterial, antioxidant and anthelmintic activities of some 4-arylidenamino-5-phenyl-4H-1,2,4-triazole-3-thiols

Three different 4-arylidenamino-5-phenyl-4H-l,2,4-triazole-3-thiols have been synthesized and their inclusion complexes are prepared with β-cyclodextrin. The compounds and their inclusion complexes have been characterized by studying their physical and spectral properties. The determination of thermodynamic stability constant and standard free energy change indicates that inclusion complexes of the newly synthesized compounds are stable and their formation is thermodynamically allowed. Finally, the compounds and their inclusion complexes are screened for antibacterial, antioxidant and anthelmintic activities. It is found that inclusion complex formation increases the antibacterial, antioxidant and anthelmintic activities significantly as compared to naked compounds. The higher pharmacological activities have been explained in terms of enhanced solubility in the systemic circulation which makes them more available to specific tissues for better therapeutic efficacy.

Synthesis and antiviral activity of benzimidazolyl-and triazolyl-1,3,5- triazines

A novel series of 1,3,5-triazine analogs was successfully synthesized through conjugation with benzimidazole or 1,2,4-triazole derivatives via a methylenethio linker. The new analogs were in vitro evaluated against HSV-1 in Vero cells; among these analogs, two compounds exhibited good effect in inhibiting HSV-1 replication (for compound 5p: EC50 = 3.5 μg/ml, SI = 358; for compound 5r: EC50 = 5.0 μg/ml, SI = 300) in comparison to acyclovir. Springer Science+Business Media, LLC 2011.