3311-57-7

Usage

Uses

Used in Pharmaceutical Industry:
Cyclohexanone, 2-(2-pyridinyl)is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into complex molecular structures, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, Cyclohexanone, 2-(2-pyridinyl)serves as an intermediate in the production of various agrochemicals, aiding in the creation of compounds that can be used in pest control and crop protection.
Used as a Solvent in Chemical Production:
Cyclohexanone, 2-(2-pyridinyl)is utilized as a solvent in the production of dyes, resins, and rubber chemicals, where its solubility properties facilitate the manufacturing process and improve the quality of the end products.
Used in Plastic and Rubber Manufacturing:
Cyclohexanone, 2-(2-pyridinyl)is also employed in the manufacturing of plastic and rubber products, where it may contribute to the modification of material properties, such as flexibility, durability, or resistance to environmental factors.
Used in Material Science Research:
Due to its unique chemical structure and properties, Cyclohexanone, 2-(2-pyridinyl)may have potential as a building block in the development of new materials, with applications spanning across various industries that require innovative material solutions.

Upstream product

• 99858-60-3 2-[2-pyridyl]cyclohexanol 
• 694-59-7 pyridine N-oxide 
• 252041-99-9 4-cyclohex-1-enyl-morpholine 
• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 5454-83-1 5-bromovaleric acid methyl ester 
• 1658-42-0 methyl 2-pyridylacetate 
• 21970-13-8 (pyridin-2-yl)magnesium bromide 
• 286-20-4 cyclohexane-1,2-epoxide 
• 101115-79-1 2-[2]pyridyl-heptanedioic acid dimethyl ester 

Downstream Products

• 525602-92-0 (3S,8S,9S,10R,13S,14S,17S)-3-Acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid 2-pyridin-2-yl-cyclohexyl ester 
• 525602-92-0 (3S,8S,9S,10R,13S,14S,17S)-3-Acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid 2-pyridin-2-yl-cyclohexyl ester 
• 99858-60-3 2-[2-pyridyl]cyclohexanol 

Relevant academic research and scientific papers

Oxidation of Nonactivated Anilines to Generate N-Aryl Nitrenoids

A low-temperature, protecting-group-free oxidation of 2-substituted anilines has been developed to generate an electrophilic N-aryl nitrenoid intermediate that can engage in C-NAr bond formation to construct functionalized N-heterocycles. The exposure of 2-substituted anilines to PIFA and trifluoroacetic acid or 10 mol percent Sc(OTf)3 triggers nitrenoid formation, followed by productive and selective C-NAr and C-C bond formation to yield spirocyclic- or bicyclic 3H-indoles or benzazepinones. Our experiments demonstrate the breadth of these oxidative processes, uncover underlying fundamental elements that control selectivity, and demonstrate how the distinct reactivity patterns embedded in N-aryl nitrenoid reactive intermediates can enable access to functionalized 3H-indoles or benzazepinones.

2-Pyridinyl β-ketones as new ligands for roomerature CuI-catalysed C-N coupling reactions

2-Pyridinyl β-ketones were identified as new efficient ligands for CuI-catalysed N-arylation of aliphatic amines at room temperature with great selectivity and substrate scope tolerance.

Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors

Screening of the Roche compound library led to the identification of cis-N-(2-phenyl-cyclohexyl)-spiropiperidine 1 as structurally novel GlyT1 inhibitor. The SAR, which was developed in this series, resulted in the discovery of highly potent compounds displaying excellent selectivity against the GlyT2 isoform.

TRIAZA-SPIROPIPERIDINE DERIVATIVES FOR USE AS GLYT-1 INHIBITORS IN THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

The invention relates to compounds of the general formula (I), wherein A-A is -CH2-CH2-, -CH2-CH2-CH2-, -CH2-0- or -0-CH2-; x is hydrogen or hydroxy; R1 is aryl or heteroaryl, unsubstituted or substituted by one or more substituents, selected from the group consisting of lower alkyl, lower alkoxy, halogen or trifluoromethyl; R2 is aryl or heteroaryl, unsubstituted or substituted by one or more substituents, selected from the group consisting of lower alkyl, lower alkoxy, halogen or trifluoromethyl, or is lower alkyl, -(CH2)n--cycloalkyl, -(CH2)n-CF3, -(CH2)p-0-lower alkyl, -(CH2)1,2-phenyl, optionally substituted by halogen, lower alkyl, lower alkoxy or trifluoromethyl, or is -(CH2)p-NRR", wherein W and R" form together with the N-atom a heterocyclic ring, selected from the group consisting of piperidine, morpholine, thiomorpholine or 1, I-dioxo thiomorpholine; R3, R4 are independently from each other hydrogen, lower alkyl, phenyl or benzyl; R5 is hydrogen, lower alkyl or benzyl; R6 is hydrogen or lower alkyl; n is 0, 1 or 2; and p is 2 or 3; and to pharmaceutically acceptable acid addition salts thereof for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.

KINTIC STUDIES ON CYCLIZATION OF 2-(2'-PYRIDYL)-CYCLOHEXANONE OXIME HYDROGENSULFATE TO 2,3-TETRAMETHYLENEPYRAZOLOPYRIDINE

Kinetic studies on cyclization of 2-(2'-pyridyl)-cyclohexanone oxime hydrogensulfate and its derivatives bearing a substituent on pyridine ring to the corresponding 2,3-tetramethylenepyrazolopyridines were carried out in buffered solutions or in presence of NaHCO3.A two-stage mechanism of the cyclization was proposed.