33118-86-4Relevant academic research and scientific papers
AMINOISOXAZOLINE COMPOUNDS AS AGONISTS OF ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTORS
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, (2017/05/19)
The present invention relates to novel aminoisoxazoline compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS
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, (2015/05/19)
The present invention relates to novel spiro-oxadiazoline compounds that are suitable as agonists or partial agonists of a7-nAChR, and pharmaceutical compositions of the same, methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering a spiro-oxadiazoline cx7-nAChR agonist or partial agonist, to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
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, (2015/11/25)
Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif
Krueger, A. Chris,Randolph, John T.,Degoey, David A.,Donner, Pamela L.,Flentge, Charles A.,Hutchinson, Douglas K.,Liu, Dachun,Motter, Christopher E.,Rockway, Todd W.,Wagner, Rolf,Beno, David W.A.,Koev, Gennadiy,Lim, Hock B.,Beyer, Jill M.,Mondal, Rubina,Liu, Yaya,Kati, Warren M.,Longenecker, Kenton L.,Molla, Akhteruzzaman,Stewart, Kent D.,Maring, Clarence J.
, p. 3487 - 3490 (2013/07/19)
The synthesis and structure-activity relationships of a novel aryl uracil series which contains a fused 5,6-bicyclic ring unit for HCV NS5B inhibition is described. Several analogs display replicon cell culture potencies in the low nanomolar range along with excellent rat pharmacokinetic values.
MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
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, (2013/06/05)
Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
The conformation and activity relationship of benzofuran derivatives as angiotensin II receptor antagonists
Yoo, Sung-Eun,Lee, Seung-Heui,Kim, Soo-Kyung,Lee, Sung-Hou
, p. 445 - 459 (2007/10/03)
We have synthesized various benzofuran derivatives to study the relationship between the conformation and the angiotensin II type I receptor antagonistic activity.
