3312-09-2Relevant academic research and scientific papers
Novel reductive Friedel-Crafts alkylation of aromatics catalyzed by indium compounds: Chemoselective utilization of carbonyl moieties as alkylating reagents
Miyai, Takashi,Onishi, Yoshiyuki,Baba, Akio
, p. 1017 - 1026 (1999)
Reductive Friedel-Crafts alkylation of aromatics with ketones or aldehydes was characteristically catalyzed by indium compounds in preference to general catalysts like AlCl3 and BF3, where hydrosilanes would play an important role both as a hydride donor and as a co-catalyst. Chemoselective utilization of ketone moieties as alkylating reagents took place even in the presence of halogen, ester or ether moieties which are very susceptible under traditional Friedel-Crafts conditions. Discussion on a plausible intermediate was carried out by some controlled experiments.
