3314-35-0Relevant articles and documents
3H-Indolium Salts Efficiently Prepared from N-Substituted Anilines and α-Branched Ketones by an One-pot Synthesis
Zimmermann, Thomas,Brede, Ortwin
, p. 103 - 108 (2004)
Starting with the N-substituted anilines 4/12 and the α-branched ketones 3 the 3H-indolium salts 1 and their fused derivatives 13 are prepared by combining a sodium nitrite nitrosation, a zinc dust reduction, a hydrazone formation and a Fischer indolization to a reaction sequence in which the isolation and purification of intermediates is not necessary. The scope and limitations of this effective one-pot synthesis are discussed.
Pharmaceutical formulations
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, (2008/06/13)
Heterocyclic compounds of formula (I) STR1 and their acid addition salts, when administered topically, exhibit anti-inflammatory activity and do not produce the side-effects associated with the administration of certain other anti-inflammatories. The compounds of formula (I) may be administered topically as the compound alone or in a suitable topical pharmaceutical formulation.
3-Trifluoroacetylamino-1-aryl-2-pyrazolines
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, (2008/06/13)
This disclosure describes novel 3-substituted amino-1-phenyl-2-pyrazolines and 3-substituted amino-1-mono and disubstituted phenyl-2-pyrazolines and their C4 and C5 analogs, useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.
