3314-35-0

Usage

Safety Profile

Poison by ingestion. Moderatelytoxic skin irritant. Severe eye irritant. When heated todecomposition it emits toxic fumes of NOx.

InChI:InChI=1/C9H11N3/c10-9-6-7-12(11-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H2,10,11)

Upstream product

• 107-13-1 acrylonitrile 
• 100-63-0 phenylhydrazine 
• 2141-62-0 3-(ethoxy)propionitrile 
• 1738-25-6 3-dimethylaminopropiononitrile 
• 26955-79-3 3-(N'-phenyl-hydrazino)-propionitrile 
• 1075-76-9 N-cyanoethylaniline 

Downstream Products

• 3314-34-9 3-Benzylidenamino-1-phenyl-Δ²-pyrazolin 
• 1128-56-9 3-amino-1-phenylpyrazole 
• 92-43-3 1-phenylpyrazolidin-3-one 
• 106087-11-0 3-Amino-1-isopropyl-1-phenyl-4,5-dihydro-1H-pyrazol-1-ium; iodide 
• 106087-12-1 3-Amino-1-butyl-1-phenyl-4,5-dihydro-1H-pyrazol-1-ium; iodide 
• 106087-13-2 3-Amino-1-isobutyl-1-phenyl-4,5-dihydro-1H-pyrazol-1-ium; iodide 
• 104573-69-5 3-amino-1-benzyl-4,5-dihydro-1-phenyl-1H-pyrazolium bromide 
• 106087-09-6 3-amino-1-ethyl-4,5-dihydro-1-phenyl-1H-pyrazolium iodide 
• 106087-10-9 3-Amino-1-phenyl-1-propyl-4,5-dihydro-1H-pyrazol-1-ium; iodide 
• 104573-70-8 1-Allyl-3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-1-ium; bromide 
• 106087-08-5 3-amino-1-methyl-1-phenyl-4,5-dihydropyrazol-1-ium iodide 
• 73031-86-4 1-Phenyl-1H-pyrazole-3-diazonium 
• 75581-26-9 1-phenyl-3-pyrazolediazonium chloride 
• 75581-25-8 C₁₈H₂₀N₆⁽²⁺⁾*2Cl^(1-) 

Relevant academic research and scientific papers

3H-Indolium Salts Efficiently Prepared from N-Substituted Anilines and α-Branched Ketones by an One-pot Synthesis

Starting with the N-substituted anilines 4/12 and the α-branched ketones 3 the 3H-indolium salts 1 and their fused derivatives 13 are prepared by combining a sodium nitrite nitrosation, a zinc dust reduction, a hydrazone formation and a Fischer indolization to a reaction sequence in which the isolation and purification of intermediates is not necessary. The scope and limitations of this effective one-pot synthesis are discussed.

AMIDRAZONES 9. CONVENIENT SYNTHESIS OF 1-ALKYL-1-PHENYLHYDRAZINES AND α,β-UNSATURATED AMIDRAZONES VIA BASE-PROMOTED REACTIONS OF 1,1-DISUBSTITUTED-3-AMNIO-4,5-DIHYDRO-1H-PYRAZOLIUM SALTS.

A simple, efficient procedure for the conversion of phenylhydrazine to 1-alkyl-1-phenylhydrazines via base-promoted hydrolysis of 1-alkyl-3-amino-4,5-dihydro-1-phenyl-1H-pyrazolium iodides (2) is described.N',N'-disubstituted hydrazones of trans-cinnamamide and acrylamide are obtained by Hofmann-type ring openings of 1,1-disubstituted-3-amino-4,5-dihydro-5-phenyl (or 5-unsubstituted) -1H-pyrazolium halides (5,7).

Pharmaceutical formulations

Heterocyclic compounds of formula (I) STR1 and their acid addition salts, when administered topically, exhibit anti-inflammatory activity and do not produce the side-effects associated with the administration of certain other anti-inflammatories. The compounds of formula (I) may be administered topically as the compound alone or in a suitable topical pharmaceutical formulation.

Therapeutically active 3-amino-1-phenyl(and substituted phenyl)-2-pyrazolines

This disclosure describes certain 3-amino-1-phenyl-2-pyrazolines and 3-amino-1-substituted phenyl-2-pyrazolines and their C4 and C5 analogs useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.

3-Trifluoroacetylamino-1-aryl-2-pyrazolines

This disclosure describes novel 3-substituted amino-1-phenyl-2-pyrazolines and 3-substituted amino-1-mono and disubstituted phenyl-2-pyrazolines and their C4 and C5 analogs, useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.