33141-33-2

Basic information

• Product Name: 3-(4-METHOXY-PHENYLAMINO)-PROPIONITRILE
• Synonyms: 3-(4-methoxyanilino)propanenitrile
• CAS NO: 33141-33-2
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.22
• Mol File: 33141-33-2.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 370.1°Cat760mmHg
• Flash Point: 177.6°C
• Appearance: /
• Density: 1.106g/cm³
• Vapor Pressure: 1.14E-05mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: 3-(4-METHOXY-PHENYLAMINO)-PROPIONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-METHOXY-PHENYLAMINO)-PROPIONITRILE(33141-33-2)
• EPA Substance Registry System: 3-(4-METHOXY-PHENYLAMINO)-PROPIONITRILE(33141-33-2)

Safety Data

• Hazardous Substances Data: 33141-33-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H12N2O/c1-13-10-5-3-9(4-6-10)12-8-2-7-11/h3-6,12H,2,8H2,1H3

Upstream product

• 5351-04-2 3-diethylaminopropionitrile 
• 20265-97-8 p-anisidine hydrochloride 
• 107-13-1 acrylonitrile 
• 5198-48-1 3-(4-methoxy-phenyl)-oxazolidin-2-one 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 28461-45-2 1-(2-Cyanoethyl)-1-(p-methoxyphenyl)-harnstoff 
• 117652-37-6 1-(4-methoxyphenyl)-4-oxopyrrolidine-3-carbonitrile 
• 138653-50-6 9-Methoxy-1,11-diphenyl-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indole 
• 138653-35-7 9-Methoxy-1-methyl-11-phenyl-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indole 
• 138653-43-7 9-Methoxy-11-methyl-1-phenyl-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indole 
• 138653-18-6 3-(5-Methoxy-3-phenyl-indol-1-yl)-propylamine 
• 138653-23-3 N-[3-(5-Methoxy-3-phenyl-indol-1-yl)-propyl]-benzamide 
• 138898-62-1 3-(5-Methoxy-3-phenyl-indol-1-yl)-propionic acid 
• 81057-35-4 3-(5-Methoxy-3-phenyl-indol-1-yl)-propionitrile 
• 117652-36-5 ethyl N-(β-cyanoethyl)-N-(4-methoxyphenyl)glycinate 

Relevant articles and documents

Synthesis and pharmacological evaluation of 3-[(4-Oxo-4H-pyrido[3,2-e][1,3]thiazin-2-yl)(phenyl)amino]propanenitrile derivatives as orally active AMPA receptor antagonists

In our search for novel orally active α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, we found that conversion of an allyl group in the lead compound 2-[allyl(4-methyl-phenyl)amino]-4H-pyrido[3,2-e][1,3]thiazin-4-one (4)

Synthesis, Characterization and Catalytic Application of MCM 41 Supported Phenanthrolinium Dibromide Catalyst for Aza-Michael Addition Reaction in Aqueous Medium

Abstract: MCM-41 immobilized phenanthrolinium dibromide (phen-MCM-Br2) was easily prepared and applied as an efficient heterogeneous catalyst for aza-Michael addition of aromatic amines to α,β-unsaturated nitriles and nitro compounds in water. The catalyst was characterized by CHN, TGA, FT-IR, SEM, EDAX, XRD, BET, and TEM. It could be simply recovered and reused several times without significant loss of catalytic activity. Graphical Abstract: [Figure not available: see fulltext.]

Polymer coated magnetically separable organocatalyst for C[sbnd]N bond formation via aza-Michael addition

A polyacrylamide coated magnetite (PAM@MNP) catalyst was synthesized by following a two step approach involving the reaction of magnetite (Fe3O4) particles with coupling agent 3-(trimethoxysilyl)propyl methacrylate followed by grafting of acrylamide and subsequent polymerization via surface initiated radical polymerization technique. The synthesized organocatalyst was used for a one-pot aza-Michael addition reaction of amines with electron deficient alkenes to give β-amino carbonyls. The magnetic properties of the synthesized organocatalyst provide it a facile recovery by external magnet which eliminates the problems arising during catalyst separation by conventional filtration.