33143-92-9Relevant academic research and scientific papers
Asymmetric epoxidation of chromenes mediated by iminium salts: Synthesis of mollugin and (3S,4R)-trans-3,4-dihydroxy-3,4-dihydromollugin
Bulman Page, Philip C.,Chan, Yohan,Noor Armylisas, Abu Hassan,Alahmdi, Mohammed
, p. 8406 - 8416 (2016/12/06)
Organocatalytic asymmetric epoxidation of chromenes mediated by iminium salt catalysts under non-aqueous conditions provided ees as high as 99%. Contrastingly, reaction under aqueous conditions can form the corresponding diol products with ees as high as 71%. The process has been used for the synthesis of the East African medicinal plant metabolite (3S,4R)-trans-3,4-dihydroxy-3,4-dihydromollugin.
ARYL AND HETEROARYL ETHER COMPOUNDS AS ROR GAMMA MODULATORS
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Page/Page column 100; 106, (2015/11/09)
The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Ring A, Ring B, R, R2, R3, n, and p are as defined herein, which are active as modulators of retinoid-related orpha
Copper-catalyzed intramolecular carbotrifluoromethylation of alkynes for the construction of trifluoromethylated heterocycles
Wang, Yanan,Jiang, Min,Liu, Jin-Tao
supporting information, p. 15315 - 15319 (2016/02/18)
A mild and efficient copper-catalyzed intramolecular carbotrifluoromethylation of alkynes has been achieved in the presence of Togni reagent as trifluoromethylating reagent. The reaction tolerates a range of substrates to give a group of trifluoromethylated heterocycles with high selectivities. A plausible mechanism was proposed on the basis of experimental results. And the Togni award goes to Copper-catalyzed intramolecular carbotrifluoromethylation of alkynes is carried out with a Togni reagent as the trifluoromethylating reagent (see scheme). Various trifluoromethylated heterocycles are synthesized in moderate to good yields. Moreover, a range of common functional groups is tolerated under the reaction conditions.
Asymmetric epoxidation of alkenes catalyzed by a porphyrin-inspired manganese complex
Dai, Wen,Li, Jun,Li, Guosong,Yang, Hua,Wang, Lianyue,Gao, Shuang
supporting information, p. 4138 - 4141 (2013/09/12)
A novel strategy for catalytic asymmetric epoxidation of a wide variety of olefins by a porphyrin-inspired chiral manganese complex using H 2O2 as a terminal oxidant in excellent yield with up to greater than 99% ee has been successfully developed.
Probing the stereoselectivity of P-glycoprotein - Synthesis, biological activity and ligand docking studies of a set of enantiopure benzopyrano[3,4-b] [1,4]oxazines
Jabeen, Ishrat,Wetwitayaklung, Penpun,Klepsch, Freya,Parveen, Zahida,Chiba, Peter,Ecker, Gerhard F.
scheme or table, p. 2586 - 2588 (2011/04/24)
A series of enantiomerically pure benzopyrano[3,4-b][1,4]oxazines have been synthesised and tested for their ability to inhibit P-glycoprotein. Reducing the conformational flexibility of the molecules leads to remarkable differences in the activity of dia
Process for the preparation of intermediates useful in the preparation of pyranyl cyanoguanidine derivatives
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, (2008/06/13)
A process for preparing compounds of the formula STR1 where a, b, c, R1, R2, and R3 are as defined herein including the step of alkylating a phenol of formula STR2 with an acetylene of formula STR3 where X is chlorine; bro
Copper(I) iodide: A catalyst for the improved synthesis of aryl propargyl ethers
Bell,Davies,Geen,Mann
, p. 707 - 712 (2007/10/02)
Copper(I) iodide catalyses the reaction between phenols and dialkylpropargyl chlorides to give aryl 1,1-dialkylpropargyl ethers 5 a-k and 7a-e in good yields and purity. These ethers are important as precursors to the 2H-1-benzopyrans 8a-l and 9a-e.
Improved Synthesis of Aryl 1,1-Dimethylpropargyl Ethers
Godfrey, Jollie D.,Mueller, Richard H.,Sedergran, Thomas C.,Soundarajan, Nachimuthu,Colandrea, Vincent J.
, p. 6405 - 6408 (2007/10/02)
An efficient, general, and practical synthesis of aryl 1,1-dimethylpropargyl ethers has been developed.
