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94535-50-9

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94535-50-9 Usage

Uses

Different sources of media describe the Uses of 94535-50-9 differently. You can refer to the following data:
1. Anti-asthmatic; antihypertensive.
2. Levcromakalim is a potassium channel activator and vasorelaxant used in the management of hypertension in diabetes mellitus.

Biological Activity

Active enantiomer of the prototypical K ATP channel opener cromakalim (trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile ). Hypotensive and airways relaxant. IC 50 = 490 nM in guinea pig trachea.

Check Digit Verification of cas no

The CAS Registry Mumber 94535-50-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,4,5,3 and 5 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 94535-50:
(7*9)+(6*4)+(5*5)+(4*3)+(3*5)+(2*5)+(1*0)=149
149 % 10 = 9
So 94535-50-9 is a valid CAS Registry Number.

94535-50-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Levcromakalim,(3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile

1.2 Other means of identification

Product number -
Other names levcromakelim

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:94535-50-9 SDS

94535-50-9Downstream Products

94535-50-9Relevant articles and documents

CONTROLLED-DELIVERY CROMAKALIM PRODRUGS

-

Page/Page column 167-169, (2021/06/22)

The present invention provides cromakalim prodrugs, compositions, and their use for the modulation of ATP-sensitive potassium (KATP) channels for therapeutic purposes.

Chiral Manganese Aminopyridine Complexes: the Versatile Catalysts of Chemo- and Stereoselective Oxidations with H2O2

Ottenbacher, Roman V.,Talsi, Evgenii P.,Bryliakov, Konstantin P.

, p. 78 - 90 (2017/10/06)

In the last decade, manganese(II) complexes with N-donor tetradentate aminopyridine ligands emerged as efficient catalysts of enantioselective epoxidation of olefins and direct selective oxidation of C?H groups in complex organic molecules, with environmentally benign oxidant hydrogen peroxide. In this personal account, we summarize the progress of these catalysts with regard to ligands design, structure-reactivity correlations, evaluation of the substrate scope, as well as mechanistic studies, shedding light on the nature of active sites and the mechanisms of selective oxygenations. Several practically promising catalytic syntheses with the aid of Mn aminopyridine catalysts are exemplified.

Immobilized dimeric chiral Mn(III) salen complex on short channel ordered mesoporous silica as an effective catalyst for the epoxidation of non-functionalized alkenes

Roy, Tamal,Kureshy, Rukhsana I.,Khan, Noor-Ul H.,Abdi, Sayed H.R.,Sadhukhan, Arghya,Bajaj, Hari C.

experimental part, p. 6314 - 6322 (2012/08/28)

Chiral dimeric Mn(III) salen complex with 1R, 2R-(-)-diaminocyclohexane collar was immobilized on short channel large pore sized silica through a long linker of {(CH2)3-NH-melamine-piperazine} to investigate its performance in enanti

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