331435-73-5Relevant articles and documents
Preparation of amides mediated by isopropylmagnesium chloride under continuous flow conditions
Munoz, Juan De M.,Alcazar, Jesus,De La Hoz, Antonio,Diaz-Ortiz, Angel,Alonso De Diego, Sergio-A.
supporting information; experimental part, p. 1335 - 1341 (2012/06/04)
A safe, green and functional-group-tolerant flow version of the direct amide bond formation mediated by Grignard reagents (the Bodroux reaction) is described. The procedure can be applied to a wide variety of primary and secondary amines and anilines, as well as to aromatic and aliphatic esters. The flow approach leads to improved yields and selectivities in the reaction, which has a sustainable purification procedure and a simple scale-up. This reaction represents an efficient and green alternative to the use of alkylaluminium and metal-catalyzed procedures.
Synthesis, spasmolytic activity and structure-activity relationship study of a series of polypharmacological thiobenzanilides
Brunhofer, Gerda,Studenik, Christian,Ecker, Gerhard F.,Erker, Thomas
scheme or table, p. 37 - 44 (2012/03/08)
Recently we presented a series of benzanilide derivatives with a selective spasmolytic effect on terminal ileum preparations of the guinea pig. In this report we demonstrate a further development of these compounds. The exchange of the amide oxygen agains
