33148-86-6

Usage

InChI:InChI=1/C7H6O3S/c1-4(8)6-2-5(3-11-6)7(9)10/h2-3H,1H3,(H,9,10)

Upstream product

• 124-38-9 carbon dioxide 
• 152538-51-7 2-(4-bromo-2-thienyl)-2-methyl-1,3-dioxolane 
• 7209-11-2 2-acetyl-4-bromothiopene 
• 13679-73-7 1-(4-methyl-thiophen-2-yl)-ethanone 

Relevant academic research and scientific papers

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Linear Free Energy Relationships in the Thiophene Series. Part 4. Acid Dissociation, Reactivity with Diazodiphenylmethane in Methanol and Analysis of 13C and 17O NMR Substituent Chemical Shifts of Some 5-Substituted Thiophene-3-carboxylic Acids. Calculation of the Substituent Constant...

The acid dissociation constants, the rate constants for the esterification with diazodiphenylmethane and the 13C and 17O NMR chemical shifts for a series of 5-substituted thiophene-3-carboxylic acids have been determined.For the sake of comparison the thermodynamic and kinetic data for a series of 4-substituted thiophene-2-carboxylic acids have been also measured.Moreover, the meta- and para-like substituent constants for the thiophene ring have been calculated by applying the Dewar and Grisdale method.The whole data show the nature of the electronic interactions between the probe system (the carboxylic group) and the meta-like substituents and the low relevance of the heteroatom both in transmitting the electronic effects of the substituents in the heterocyclic system and in interfering sterically with the present substituents.

LIQUID-PHASE OXIDATION OF METHYLACETOTHIENONES WITH COBALT-BROMIDE CATALYST

The oxidation of four isomeric methylacetothienones by molecular oxygen in acetic acid in the presence of cobalt-bromide catalyst was investigated.The reaction leads to the formation of the corresponding keto carboxylic acid.The keto aldehydes are intermediate products.