331647-95-1Relevant academic research and scientific papers
Palladium-catalyzed oxidative C–H/C–H cross-coupling of pyrazolo[1,5-
Nguyen, Thanh V. Q.,Poli, Lorenzo,Garrison, Aaron T.
supporting information, p. 827 - 830 (2022/02/01)
The use of Pd(OAc)2 as the catalyst and AgOAc as the oxidant enabled the direct regioselective oxidative C–H/C–H cross-coupling of pyrazolo[1,5-a]pyrimidines or pyrazolo[1,5-a]pyridines with various five-membered heteroarenes without the need of pre-activation and/or directing groups. Successful coupling partners include thiophenes, benzothiophenes, thiazoles, furans, oxazoles, indoles and imidazo[1,2-a]pyridines.
ALK5 INHIBITORS
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Paragraph 0479; 0492; 0493, (2020/07/07)
The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.
