331729-65-8Relevant academic research and scientific papers
Convenient Assembly of Privileged (Hetero)Arene-Fused Benzo[1.4]oxazepines via Two Tandem SNAr Events. Part 1 – On the Importance of the Intermittent Smiles Rearrangement
Sapegin, Alexander,Krasavin, Mikhail
, p. 5234 - 5241 (2019)
New bis-nucleophilic precursors to [1.4]oxazepines synthesized via SNAr-Smiles rearrangement-SNAr cascade have been designed. Employing them in base-promoted condensation with aromatic bis-electrophiles allowed differentiating between highly and poorly reactive substrates (i.e. those which can and cannot pass through the Smiles rearrangement barrier, respectively). The reactivity toward the desired course of cyclization can be restored by introducing electron-withdrawing substituents in the bis-electrophile precursor. This strongly argues for the importance of the Smiles rearrangement for the successful overall ring formation.
Compounds for the treatment of ischemia
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Page 63, (2010/02/08)
A3 agonists, methods of using such A3 agonists and pharmaceutical compositions containing such A3 agonists. The A3 agonists are useful for the reduction of tissue damage resulting from tissue ischemia or hypoxia
