331746-72-6

Basic information

• Product Name: 3-Pyridinemethanol, 6-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-
• CAS NO: 331746-72-6
• Molecular Formula: C18H18N2O3
• Molecular Weight: 310.353
• Mol File: 331746-72-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 529.1±60.0 °C(Predicted)
• Density: 1?+-.0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-Pyridinemethanol, 6-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinemethanol, 6-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-(331746-72-6)
• EPA Substance Registry System: 3-Pyridinemethanol, 6-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-(331746-72-6)

Safety Data

• Hazardous Substances Data: 331746-72-6(Hazardous Substances Data)

Upstream product

• 784149-29-7 5-bromo-2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine 
• 331745-78-9 6-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-nicotinic acid methyl ester 
• 103788-65-4 (5-methyl-2-phenyloxazol-4-yl)ethanol 
• 624-28-2 2,5-dibromopyridine 
• 157169-61-4 5-formyl-2-[2-(5-methyl-2-phenyl-4-oxazolyl)-ethoxy]pyridine 

Downstream Products

• 784149-40-2 5-(iodomethyl)-2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine 
• 919361-00-5 2-methyl-3-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-yl}-propionic acid 
• 784148-47-6 2-methoxy-2-methyl-3-{6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}propanoic acid 
• 1058704-27-0 2-methoxy-3-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-yl}-propionic acid ethyl ester 
• 784149-92-4 ethyl 2-ethoxy-3-{6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}propanoate 

Relevant articles and documents

Pyridine-3-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents

A series of novel pyridine-3-propanoic acids was synthesized. A structure-activity relationship study of these compounds led to the identification of potent dual PPARα/γ agonists with varied isoform selectivity. Based on the results of efficacy studies in

ALPHA SUBSTITUTED CARBOXYLIC ACID AS PPAR MODULATORS

Alpha substituted carboxylic acids of formula (I): wherein R' and R2 are as defined in the specification and R3 is A) formula (II); B) formula (III); C) formula (IV); and D) formula (V); wherein Y, Art, Are, AP, R4, R5, R6, R7, R6, R9, R9a, R10, R", R12, R17, ring A, and p are as defined in the specification; pharmaceutical compositions containing effective amounts of said compounds or their salts are useful for treating PPAR, specifically PPAR α/y related disorders, such as diabetes, dyslipidemia, obesity and inflammatory disorders.

Antidiabetic agents

The present invention provides compounds of Formula (I): wherein A, X, Q, Y, B, D, Z, and E have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful as antidiabetic agents. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, processes for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.