784149-47-9Relevant academic research and scientific papers
Pyridine-3-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents
Humphries, Paul S.,Bailey, Simon,Almaden, Jonathon V.,Barnum, Sandra J.,Carlson, Thomas J.,Christie, Lance C.,Do, Quyen-Quyen T.,Fraser, James D.,Hess, Mary,Kellum, Jack,Kim, Young H.,McClellan, Guy A.,Ogilvie, Kathleen M.,Simmons, Brett H.,Skalitzky, Donald,Sun, Shaoxian,Wilhite, David,Zehnder, Luke R.
, p. 6120 - 6123 (2007/10/03)
A series of novel pyridine-3-propanoic acids was synthesized. A structure-activity relationship study of these compounds led to the identification of potent dual PPARα/γ agonists with varied isoform selectivity. Based on the results of efficacy studies in
Intermolecular palladium-catalyzed coupling of 2-halopyridines and alcohols for the preparation of pyridine ether PPAR agonists
Humphries, Paul S.,Bailey, Simon,Do, Quyen-Quyen T.,Kellum, Jack H.,McClellan, Guy A.,Wilhite, David M.
, p. 5333 - 5336 (2007/10/03)
A series of pyridine ether PPAR agonists were synthesized through intermolecular palladium-catalyzed coupling of 2-halopyridines and alcohols. This method proved to be versatile, efficient, and amenable to parallel synthesis.
Alpha substituted carboxylic acids
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, (2008/06/13)
Alpha substituted carboxylic acids of formula (I):
ALPHA SUBSTITUTED CARBOXYLIC ACID AS PPAR MODULATORS
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Page 117, (2010/02/09)
Alpha substituted carboxylic acids of formula (I): wherein R' and R2 are as defined in the specification and R3 is A) formula (II); B) formula (III); C) formula (IV); and D) formula (V); wherein Y, Art, Are, AP, R4, R5, R6, R7, R6, R9, R9a, R10, R", R12, R17, ring A, and p are as defined in the specification; pharmaceutical compositions containing effective amounts of said compounds or their salts are useful for treating PPAR, specifically PPAR α/y related disorders, such as diabetes, dyslipidemia, obesity and inflammatory disorders.
