331833-99-9

Basic information

• Product Name: 5-bromobenzofuran-2-ylboronic acid
• Synonyms: 5-bromobenzofuran-2-ylboronic acid;5-bromobenzofuran-3-ylboronic acid;Boronic acid, B-(5-bromo-2-benzofuranyl)-
• CAS NO: 331833-99-9
• Molecular Formula: C₈H₆BBrO₃
• Molecular Weight: 240.84644
• Mol File: 331833-99-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 396.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.76±0.1 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 5.84±0.30(Predicted)
• CAS DataBase Reference: 5-bromobenzofuran-2-ylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromobenzofuran-2-ylboronic acid(331833-99-9)
• EPA Substance Registry System: 5-bromobenzofuran-2-ylboronic acid(331833-99-9)

Safety Data

• Hazardous Substances Data: 331833-99-9(Hazardous Substances Data)

Usage

General Description

5-Bromobenzofuran-2-ylboronic acid is a chemical compound composed of a benzofuran ring with a bromine atom at the 5-position and a boronic acid group attached at the 2-position. It is commonly used as a building block in organic synthesis, particularly in the field of medicinal chemistry and the development of pharmaceuticals. The boronic acid functionality allows for the compound to participate in Suzuki-Miyaura cross-coupling reactions, making it a versatile and valuable reagent for the formation of carbon-carbon bonds. 5-bromobenzofuran-2-ylboronic acid has been employed in the synthesis of various biologically active molecules and has potential applications in drug discovery and development. Additionally, it has been investigated for its properties as a fluorescent reagent in chemical biology studies.

Upstream product

• 23145-07-5 5-bromobenzofuran 
• 129969-69-3 1-bromo-4'-(2,2-dimethoxyethoxy)benzene 
• 106-41-2 4-bromo-phenol 

Downstream Products

• 331834-00-5 5-bromo-2-(4-pentyl-phenyl)-benzofuran 
• 1246472-09-2 C₁₄H₇Br₂FO 
• 132114-11-5 ratanhine 
• 943341-57-9 C₄₀H₃₈O₈ 
• 943341-65-9 C₂₀H₂₁BO₆ 

Relevant articles and documents

INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

The synthesis and transition temperatures of 2-(4-alkyl- and 4-alkoxy-phenyl)-5-cyano-1-benzofurans and related diaryl-1-benzofurans - An assessment of how deviations from linearity and conformational effects in a core unit affect mesogenicity

The synthesis and transition temperatures are reported for several 2-(4-alkyl- and 4-alkoxy-phenyl)-5-cyano-1-benzofurans, 2-(4′-alkylbiphenyl-4-yl)-5-cyano- and 5-(4′-alkylbiphenyl-4-yl)-2-cyano-1-benzofurans, and for compounds with other combinations of terminal alkyl and cyano groups in 2,5-disubstituted-1-benzofurans containing two phenyl units, some isolated examples of related cyclohexane systems are also presented. The mesogenic behaviour of these compounds and several intermediates (e.g. amides, acids and esters) is discussed and the transition temperatures are rationalised on the following basis (a) 1-benzofuran is a superior core unit to benzene, (b) 2,5-disubstitution in 1-benzofuran gives a bent core which adversely affects mesogenicity, to an extent which depends on its position in the core, (c) antiparallel associations in terminal cyano compounds can eliminate the disadvantage of a bent core structure, (d) 2-aryl-1-benzofurans have negligible inter-annular twist but 5-aryl-1-benzofurans have similar inter-annular twist to that in biphenyls.