33185-56-7

Upstream product

• 887144-97-0 Togni's reagent 
• 1121-24-0 ortho-mercaptophenol 
• 2314-97-8 iodotrifluoromethane 
• 456-56-4 phenyl trifluoromethylsulfide 

Downstream Products

• 647856-39-1 4-bromo-2-[(trifluoromethyl)sulfanyl]phenol 

Relevant academic research and scientific papers

Catalytic borylation of SCF3-functionalized arenes by rhodium(I) boryl complexes: Regioselective C-H activation at the ortho-position

An unprecedented reaction pathway for the borylation of SCF 3-containing arenes using [Rh(Bpin)(PEt3)3] (pin=pinacolato) is reported. Catalytic processes were developed and the functionalizations proceed under mild reaction conditions. The C-H activations occur with a unique regioselectivity for the position ortho to the SCF 3 group, which apparently serves as directing group. Borylated SCF3 compounds can serve as versatile building blocks. SCF 3 building blocks: A unique reaction route allows access to SCF 3-functionalized arenes, which are borylated at the ortho-position. The functionalization proceeds by C-H borylation with [Rh(Bpin)(PEt 3)3] (pin=pinacolato), and the SCF3 group likely serves as directing group. The generated borylated SCF3 compounds are versatile building blocks for further transformations.

Recent advances in electrophilic CF3-transfer using hypervalent iodine(III) reagents

The development of new methodologies for an efficient introduction of CF3 groups into complex molecules constitutes one of the most challenging tasks of modern organic chemistry. Recently, we reported the access to a new class of electrophilic CF3-transfer reagents based on hypervalent iodine. The versatile application of these reagents to C-centred nucleophiles, such as β-keto esters, silyl enol ethers and α-nitro esters, as well as to thiols and primary and secondary phosphines is described. Experiments with phenols afforded corresponding trifluomethylethers in very low yields. Schweizerische Chemische Gesellschaft.

Mild electrophilic trifluoromethylation of carbon- and sulfur-centered nucleophiles by a hypervalent iodine(III)-CF3 reagent

Inexpensive, recyclable, and activable: these are the features of a new mild electrophilic trifluoromethylation reagent that can be used to transfer a CF3 group to C-centered nucleophiles, such as β-keto esters and α-nitro esters, and to S-centered nucleophiles (see scheme). (Chemical Equation Presented).

N-HYDROXYAMIDE DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY

Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.

Process for preparing perfluoroalkyl aryl sulfides and novel perfluoroalkyl aryl sulfides

This invention relates to a process for preparing perfluoroalkyl aryl sulfides by reaction of disulfides with alkali metal salts of aliphatic perfluorocarboxylic acids in the presence of a high-boiling aprotic solvent at elevated temperature and reduced pressure, wherein the product formed is distilled off at the rate at which it is formed. This invention further relates to the novel compounds 2-nitrophenyl pentafluoroethyl sulfide and 2-aminophenyl pentafluoroethyl sulfide.