33189-02-5

Basic information

• Product Name: 4-Methoxy-1-naphthalenepropionic Acid
• Synonyms: 4-Methoxy-1-naphthalenepropanoic Acid;4-Methoxy-1-naphthalenepropionic Acid
• CAS NO: 33189-02-5
• Molecular Formula: C14H14O3
• Molecular Weight: 230.25916
• Mol File: 33189-02-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 165-166 °C
• Boiling Point: 419.9±20.0 °C(Predicted)
• Appearance: /
• Density: 1.202±0.06 g/cm3(Predicted)
• PKA: 4.52±0.10(Predicted)
• CAS DataBase Reference: 4-Methoxy-1-naphthalenepropionic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-1-naphthalenepropionic Acid(33189-02-5)
• EPA Substance Registry System: 4-Methoxy-1-naphthalenepropionic Acid(33189-02-5)

Safety Data

• Hazardous Substances Data: 33189-02-5(Hazardous Substances Data)

Usage

Chemical Properties

4-Methoxy-1-naphthalenepropionic Acid is Solid

Uses

Different sources of media describe the Uses of 33189-02-5 differently. You can refer to the following data:
1. 4-Methoxy-1-naphthalenepropionic Acid can be used in the synthesis of coumarin and realated compounds, vanilloid TRPV3 modulators and pharmacologically important carboxylic acids.
2. Synthetic intermediate that can be used in the synthesis of coumarin and realated compounds, vanilloid TRPV3 modulators and pharmacologically important carboxylic acids.

Upstream product

• 861354-99-6 ethyl 3-(4'-methoxy-1'-naphthyl)propanoate 
• 15971-31-0 ethyl 3-(4'-methoxy-1'-naphthyl)-2-propenoate 
• 16820-54-5 1-hydroxymethyl-4-methoxy-naphthalene 
• 15971-29-6 4-methoxy-1-naphthaldehyde 
• 2216-69-5 1-Methoxynaphthalene 
• 27230-52-0 β-(8-methoxy-2-oxo-1,2,3,4-tetrahydro-5-naphthyl)propionic acid 
• 22442-52-0 β-(4,6-dimethoxy-1-naphthyl)-propionic acid 
• 70179-57-6 β-(8-methoxy-1,2,3,4-tetrahydro-5-naphthyl)-propionic acid 
• 50-00-0 formaldehyd 
• 15971-30-9 3-(4-methoxynaphthalen-1-yl)acrylic acid 
• 33302-59-9 β-(4-Methoxy-1-naphthyl)-propionitril 
• 77260-03-8 methyl β-(8-methoxy-1,2,3,4-tetrahydro-5-naphthyl)-propionate 
• 5471-38-5 1-(4-methoxy-[1]naphthyl)-propan-1-one 

Downstream Products

• 1613625-20-9 C₂₄H₂₂N₄O₄ 
• 1613625-26-5 (S)-methyl 3-{4-[4-(benzyloxycarbonylamino)but-1-ynyl]naphthalen-1-yl}-2-(tert-butoxycarbonylamino)propanoate 
• 1613625-27-6 (S)-3-{4-[4-(benzyloxycarbonylamino)but-1-ynyl]naphthalen-1-yl}-2-(tert-butoxycarbonylamino)propanoic acid 
• 1613625-28-7 C₃₀H₃₃N₃O₅ 
• 1613625-30-1 C₃₀H₃₇N₃O₅ 
• 1613625-31-2 C₂₅H₂₉N₃O₃*ClH 
• 1613625-32-3 C₃₃H₄₄N₄O₅ 
• 1613625-33-4 C₄₁H₅₀N₄O₇ 
• 1613625-34-5 C₃₆H₄₂N₄O₅ 
• 1613625-19-6 C₂₄H₂₃NO₄ 
• 3352-82-7 6-Hydroxyphenalenone 

Relevant articles and documents

Evaluation of synthetic naphthalene derivatives as novel chemical chaperones that mimic 4-phenylbutyric acid

The chemical chaperone 4-phenylbutyric acid (4-PBA) has potential as an agent for the treatment of neurodegenerative diseases. However, the requirement of high concentrations warrants chemical optimization for clinical use. In this study, novel naphthalene derivatives with a greater chemical chaperone activity than 4-PBA were synthesized with analogy to the benzene ring. All novel compounds showed chemical chaperone activity, and 2 and 5 possessed high activity. In subsequent experiments, the protective effects of the compounds were examined in Parkinson's disease model cells, and low toxicity of 9 and 11 was related to amphiphilic substitution with naphthalene.

3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS

The present invention relates compounds of the formula: or pharmaceutically acceptable salts thereof, useful as sodium channel blockers, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including cystic fibrosis, chronic obstructive pulmonary disease, asthma, bronchiectasis, acute and chronic bronchitis, emphysema, and pneumonia.