3319-28-6

Basic information

• Product Name: 1H-Benzimidazole-2-methanol,alpha,1-dimethyl-(9CI)
• Synonyms: 1H-Benzimidazole-2-methanol,alpha,1-dimethyl-(9CI);α,1-Dimethyl-1H-benzimidazole-2-methanol;1-(1-methylbenzimidazol-2-yl)ethanol;1-(1-methyl-1H-benzo[d]imidazol-2-yl)ethan-1-ol
• CAS NO: 3319-28-6
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.21508
• Product Categories: BENZIMIDAZOLE
• Mol File: 3319-28-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 343.1°Cat760mmHg
• Flash Point: 161.3°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 2.75E-05mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 1H-Benzimidazole-2-methanol,alpha,1-dimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-2-methanol,alpha,1-dimethyl-(9CI)(3319-28-6)
• EPA Substance Registry System: 1H-Benzimidazole-2-methanol,alpha,1-dimethyl-(9CI)(3319-28-6)

Safety Data

• Hazardous Substances Data: 3319-28-6(Hazardous Substances Data)

Usage

Classification

Benzimidazole derivative This compound belongs to a class of chemical compounds known as benzimidazoles, which are heterocyclic aromatic organic compounds.

Appearance

White to off-white crystalline The compound has a solid, crystalline form with a white to off-white color.

Solubility

Soluble in organic solvents This compound can dissolve in certain organic solvents, which is important for its use in chemical reactions and synthesis.

Use as an intermediate

Synthesis of pharmaceuticals and organic compounds 1H-Benzimidazole-2-methanol, alpha,1-dimethyl-(9CI) is commonly used as a starting material or intermediate in the production of other chemical compounds, including pharmaceuticals.

Pharmaceutical applications

Anti-cancer and anti-inflammatory properties Research has shown that this compound has potential pharmaceutical applications due to its ability to inhibit cancer cell growth and reduce inflammation.

Inhibitory effects on enzymes

Medicinal and biochemical research interest The compound is known to have inhibitory effects on certain enzymes, making it a valuable tool in the study of enzyme function and the development of new drugs.

InChI:InChI=1/C10H12N2O/c1-7(13)10-11-8-5-3-4-6-9(8)12(10)2/h3-7,13H,1-2H3

Upstream product

• 77-78-1 dimethyl sulfate 
• 16414-04-3 1-benzimidazol-2-ylethanol 
• 74-88-4 methyl iodide 
• 1493-27-2 ortho-nitrofluorobenzene 
• 612-28-2 2-nitro-N-methylaniline 
• 4760-34-3 N-methyl-1,2-phenylenediamine 
• 183244-70-4 2-(1-acetoxy-ethyl)-1H-benzimidazole 
• 849585-22-4 LACTIC ACID 
• 942-25-6 2-acetyl-1-methylbenzimidazole 
• 25148-68-9 N-methylbenzene-1,2-diamine dihydrochloride 
• 944061-74-9 C₁₂H₁₄N₂O₂ 

Downstream Products

• 58282-03-4 1-methyl-2-(α-chloroethyl)benzimidazole 
• 1237776-30-5 1-methyl-2-(1-phenylethyl)-1H-benzo[d]imidazole 
• 152706-67-7 1-(1-methyl-1H-benzoimidazol-2-yl)-3-(4-nitro-phenyl)-propenone 
• 3319-27-5 1-(1-methyl-1H-benzoimidazol-2-yl)-3-phenyl-propenone 
• 132308-87-3 1-(1-methyl-2-benzimidazolyl)-3-(p-anisyl)-2-propen-1-one 
• 132308-88-4 (E)-3-(4-Chloro-phenyl)-1-(1-methyl-1H-benzoimidazol-2-yl)-propenone 
• 132308-86-2 (E)-1-(1-Methyl-1H-benzoimidazol-2-yl)-3-p-tolyl-propenone 
• 942-25-6 2-acetyl-1-methylbenzimidazole 

Relevant articles and documents

Synthesis of O,C-dilithium derivatives of 2-(α-hydroxyalkyl)-1-methylbenzimidazoles [4]

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Synthesis, crystal structure, and antioxidant property of a new Co(III) coordination polymer based on ligand (E)-2-{2-[1-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylidene]hydrazinyl}benzo[d]thiazole

A new Co(III) complex, [CoL2](ClO4)(CH3CN) (1) (HL = (E)-2-{2-[1-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylidene]hydrazinyl}benzo[d]thizole), has been prepared by solvent evaporation method, and characterized by single-crystal X-ray diffraction, bond valence sum, and elemental analysis. The result of single-crystal X-ray diffraction analysis indicates that each Co(III) ion is six-coordinated by six nitrogen atoms from two L- to form distorted octahedral geometry. The hydrogen bonds and π.π stacking interactions ensure the cohesion of crystal lattice in a 3D supramolecular framework in the solid state. The antioxidant activities of HL and 1 were also studied.

Synthesis and antiprotozoal activity of novel 1-methylbenzimidazole derivatives

In this paper are reported the synthesis and antiprotozoal activity in vitro of 24 1-methylbenzimidazole derivatives (13-36) substituted at position 2 with aminocarbonyl, N-methylaminocarbonyl, N,N-dimethylaminocarbonyl, ethoxycarbonyl, 1-hydroxyethyl and acetyl groups, some of them with chlorine atoms at the benzenoid ring. Compounds 13-36 were more active than metronidazole, the choice drug against Giardia intestinalis and most of them against Trichomonas vaginalis. The most active group of compounds for both parasites was that with a 2-ethoxycarbonyl group (16, 22, 28, 34), independently of the substitution pattern at the benzenoid ring.