331949-55-4

Usage

Uses

Used in Pharmaceutical Synthesis:
1H-Benzimidazole-2-methanol,6-chloro-1-methyl-(9CI) is used as a key intermediate in the synthesis of various pharmaceuticals for its unique chemical properties and potential therapeutic applications.
Used in Antiparasitic Applications:
In the field of antiparasitic agents, 1H-Benzimidazole-2-methanol,6-chloro-1-methyl-(9CI) is used as a potential treatment for parasitic infections due to its ability to target and disrupt essential biological processes within parasites.
Used in Antifungal Applications:
1H-Benzimidazole-2-methanol,6-chloro-1-methyl-(9CI) is utilized as an antifungal agent, leveraging its chemical structure to inhibit fungal growth and treat infections caused by various fungal species.
Used in Cancer Treatment Research:
In oncology, 1H-Benzimidazole-2-methanol,6-chloro-1-methyl-(9CI) is studied for its potential role in the treatment of cancer, as it may exhibit properties that can target cancer cells and inhibit their proliferation.
Used in Infectious Disease Treatment Research:
1H-Benzimidazole-2-methanol,6-chloro-1-methyl-(9CI) is also being investigated for its potential in treating various infectious diseases, suggesting that it may have broad-spectrum antimicrobial activity, which could be beneficial in combating drug-resistant pathogens.

Upstream product

• 79-14-1 glycolic Acid 
• 84859-27-8 5-chloro-N¹-methylbenzene-1,2-diamine 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 156212-81-6 6-Chloro-1-methyl-1H-benzoimidazole-2-carbaldehyde 

Relevant academic research and scientific papers

Synthesis and antinociceptive activity of meperidine-like benzimidazole derivatives

(Graph presented) A series of novel benzimidazole derivatives have been prepared and characterized by IR, 1H-NMR spectroscopic data and elemental analysis. All the final compounds were screened for their antinociceptive activities with tail flick test. Among the synthesized compounds 3a, 4a, 4c, 8a, 9a exhibited significant antinociceptive activity. Compound 9a was found to have the highest antinociceptive activity at both 60 minutes and 120 minutes. Additionally, compounds 3a, 4a, 8a and 9a showed naloxone-reversible antinociceptive activity.

Synthesis and antiprotozoal activity of novel 1-methylbenzimidazole derivatives

In this paper are reported the synthesis and antiprotozoal activity in vitro of 24 1-methylbenzimidazole derivatives (13-36) substituted at position 2 with aminocarbonyl, N-methylaminocarbonyl, N,N-dimethylaminocarbonyl, ethoxycarbonyl, 1-hydroxyethyl and acetyl groups, some of them with chlorine atoms at the benzenoid ring. Compounds 13-36 were more active than metronidazole, the choice drug against Giardia intestinalis and most of them against Trichomonas vaginalis. The most active group of compounds for both parasites was that with a 2-ethoxycarbonyl group (16, 22, 28, 34), independently of the substitution pattern at the benzenoid ring.