332-50-3

Usage

Uses

Used in Organic Synthesis:
2-(4-fluorophenoxy)acetamide is utilized as a building block in organic synthesis for the creation of more complex molecules. Its unique structure allows for the development of new compounds with specific properties, making it a versatile component in the synthesis of pharmaceuticals and other organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-(4-fluorophenoxy)acetamide is employed as a starting material for the development of new drugs. Its ability to modulate biological processes is under investigation for potential therapeutic applications, highlighting its importance in the discovery of novel medications.
Used in Anti-inflammatory and Analgesic Drug Development:
2-(4-fluorophenoxy)acetamide is being studied for its anti-inflammatory and analgesic properties. It holds promise as a compound in the development of new drugs aimed at treating pain and inflammation, potentially offering improved efficacy and reduced side effects compared to existing treatments.

InChI:InChI=1/C8H8FNO2/c9-6-1-3-7(4-2-6)12-5-8(10)11/h1-4H,5H2,(H2,10,11)

Upstream product

• 405-78-7 2-(4-fluorophenoxy)acetyl chloride 
• 36161-26-9 potassium 4-fluorophenoxide 
• 79-07-2 Chloroacetamide 
• 405-79-8 2-(4-fluorophenoxy)ethanoic acid 
• 371-41-5 4-Fluorophenol 

Downstream Products

• 6096-89-5 2-(4-fluorophenoxy)-1-ethylamine 
• 1644-58-2 β-(p-Fluorophenoxy)ethyliminodiacetic acid 

Relevant academic research and scientific papers

A phenoxy acetyl amine compound preparation method and phenoxy acetamide compounds

The invention belongs to the organic intermediates and the technical field of pharmaceutical intermediates, in particular to a phenoxy acetyl amine compound preparation method and phenoxy acetyl amine compound. The present invention provides a preparation method of the pervasive should be good, and green environmental protection, has better popularization and application value. The results show that the embodiment, the invention provides the above-mentioned method can prepare a plurality of phenoxy acetyl amine compound, and the yield can be 76%.

Synthesis and biological evaluation of 2-Phenoxyacetamide analogues, a novel class of potent and selective monoamine oxidase inhibitors

Monoamine oxidases (EC 1.4.3.4; MAOs), a family of FAD-containing enzymes, is an important target for antidepressant drugs. In this paper, a series of 2-phenoxyacetamide analogues were synthesized, and their inhibitory potency towards monoamine oxidases A (MAO-A) and B (MAO-B) were evaluated using enzyme and cancer cell lysate. 2-(4-Methoxyphenoxy)acetamide (compound 12) (SI = 245) and (2-(4-((prop-2- ynylimino)methyl)phenoxy)acetamide (compound 21) (IC50MAO-A = 0.018 μM, IC50MAO-B = 0.07 μM) were successfully identified as the most specific MAO-A inhibitor, and the most potent MAO-A/-B inhibitor, respectively. The inhibitory activities of these two compounds in living cells were also further evaluated utilizing HepG2 and SHSY-5Y cell lysates.