332-83-2Relevant academic research and scientific papers
PROCESS FOR PRODUCING ALDEHYDE COMPOUND OR KETONE COMPOUND WITH USE OF MICROREACTOR
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Page/Page column 22-23; 36; 38-39, (2010/11/24)
The method for producing an aldehyde or ketone compound from a corresponding primary or secondary alcohol at relatively high temperature within a short time with a high yield comprises a step (1) of reacting a sulfoxide compound with an activating agent to produce an activation reaction product; a step (2) of reacting the activation reaction product with a primary or secondary alcohol to produce an alkoxysulfonium salt; and a step (3) of reacting the reaction product with a base to produce an aldehyde or ketone; wherein at least one of the steps, preferably the step (1) and step (2), are carried out by using a microreactor.
Halide assisted addition of hydrogen halides to alkenes
Weiss, Hilton M.,Touchette, Kim M.
, p. 1517 - 1522 (2007/10/03)
The addition of 0.1 M quaternary ammonium halide to a solution of 20% trifluoroacetic acid in methylene chloride causes a large rate increase in the reaction of simple alkenes leading to a mixture of alkyl halides and trifluoroacetates. The mechanism is proposed to involve a halide assisted protonation of the alkene which produces a carbocation intermediate sandwiched between the attacking halide ion and the trifluoroacetate ion. At higher concentrations of halide ion, the proton donating ability of the solution decreases, slowing the reaction and increasing the efficiency of cation capture by the halide ion. This leads to a greater proportion of unrearranged halide product. At the highest concentration of halide ion, cation rearrangement is virtually eliminated.
