332041-08-4

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 102997-58-0 (1R,2R,3S)-tris(phenylmethoxy)-6S-hydroxy-cyclohex-4-ene 

Downstream Products

• 332041-16-4 methyl 2,3,4-tri-O-benzyl-6-deoxy-6-{(2aS,4aS,5S,6S,7R,7aR,7bR)-5,6,7-tris(benzyloxy)octahydro-2H-furo[4,3,2-c,d]-1,2-benzisoxazol-2-yl}-α-D-glucopyranoside 
• 332041-10-8 (2aS,4aS,5S,6S,7R,7aR,7bR)-2-benzyl-5,6,7-tris(benzyloxy)octahydro-2H-furo[4,3,2-c,d][1,2]benzisoxazole 
• 332041-11-9 (2aS,4aS,5S,6S,7R,7aR,7bR)-5,6,7-tris(benzyloxy)-2-methyloctahydro-2H-furo[4,3,2-c,d][1,2]benzisoxazole 
• 332041-09-5 2-[(1S,4S,5R,6S)-4,5,6-tris(benzyloxy)cyclohex-2-enyloxy]acetaldehyde 

Relevant academic research and scientific papers

A novel approach to anellated carbasugar derivatives, using intramolecular 1,3-dipolar cycloaddition reactions of sugar-derived nitrones

Intramolecular 1,3-dipolar cycloaddition of the intermediate nitrones 5 and 6 to double bonds stereoselectively yielded the benzylated anellated carbasugar derivatives 7 and 8. The disaccharide analogue 14 was synthesized similarly. Deprotection afforded the anellated carbasugars 9, 10, and 15, which were investigated as potential inhibitors of glycosidases. This paper also describes the theoretical and experimental evaluation of these compounds as ligands for different enzymes, using automatic docking procedures and enzyme assays, respectively.