33205-72-0Relevant academic research and scientific papers
Synthesis of 3-adamantylated hydantoins and their 2-thio(seleno) analogs
Burmistrov, Vladimir V.,Pitushkin, Dmitry А.,Vasipov, Vladimir V.,D’yachenko, Vladimir S.,Butov, Gennady M.
, p. 619 - 622 (2019)
[Figure not available: see fulltext.] A series of 3-(adamantan-1-ylalkyl)-2-(O,S,Se)hydantoins were synthesized in the reaction of (adamantan-1-ylalkyl)heteroallenes with glycine ethyl ester hydrochloride under mild conditions in 75–85% yields. A method was developed for the synthesis of novel adamantan-1-ylalkyl isoselenocyanates, precursors in the synthesis of adamantylated 2-selenohydantoins. For the first time, 3-(adamantan-1-yl)-2-(O,S)hydantoins were synthesized via the reaction of 2-(O,S)hydantoins with 1,3-dehydroadamantane in 1,4-dioxane heated to reflux for 1 h in 75–80% yields.
Discovery of a series of ester-substituted NLRP3 inflammasome inhibitors
Harrison, David,Boutard, Nicolas,Brzozka, Krzysztof,Bugaj, Marta,Chmielewski, Stefan,Cierpich, Anna,Doedens, John R.,Fabritius, Charles-Henry R.Y.,Gabel, Christopher A.,Galezowski, Michal,Kowalczyk, Piotr,Levenets, Oleksandr,Mroczkowska, Magdalena,Palica, Katarzyna,Porter, Roderick A.,Schultz, David,Sowinska, Marta,Topolnicki, Grzegorz,Urbanski, Piotr,Woyciechowski, Jakub,Watt, Alan P.
supporting information, (2020/10/02)
The NLRP3 inflammasome is a component of the innate immune system involved in the production of proinflammatory cytokines. Aberrant activation by a wide range of exogenous and endogenous signals can lead to chronic, low-grade inflammation. It has attracted a great deal of interest as a drug target due to the association with diseases of large unmet medical need such as Alzheimer's disease, Parkinson's disease, arthritis, and cancer. To date, no drugs specifically targeting inhibition of the NLRP3 inflammasome have been approved. In this work, we used the known NLRP3 inflammasome inhibitor CP-456,773 (aka CRID3 or MCC 950) as our starting point and undertook a Structure-Activity Relationship (SAR) analysis and subsequent scaffold-hopping exercise. This resulted in the rational design of a series of novel ester-substituted urea compounds that are highly potent and selective NLRP3 inflammasome inhibitors, as exemplified by compounds 44 and 45. It is hypothesized that the ester moiety acts as a highly permeable delivery vehicle and is subsequently hydrolyzed to the carboxylic acid active species by carboxylesterase enzymes. These molecules are greatly differentiated from the state-of-the-art and offer potential in the treatment of NLRP3-driven diseases, particularly where tissue penetration is required.
