33207-99-7Relevant academic research and scientific papers
Organocatalytic enantioselective multicomponent synthesis of pyrrolopiperazines
Du, Haiying,Rodriguez, Jean,Bugaut, Xavier,Constantieux, Thierry
, p. 851 - 856 (2014)
The first organocatalytic multicomponent synthesis of enantioenriched pyrrolopiperazines is reported. These biologically relevant fused tricyclic products were obtained under catalytic iminium activation through a reaction sequence involving an enantioselective Michael addition followed by an iminium ion trapping via Pictet-Spengler cyclization (MAPS sequence). Substantial possibilities for variation on the three reaction partners [β-keto ester, enal and N-(2-aminoethyl)pyrrole] along with excellent enantioselectivities are the highlights of the present transformation.
