332124-25-1

Upstream product

• 13057-17-5 bromethyl methyl ether 
• 766-85-8 3-methoxy-1-iodobenzene 
• 1379329-63-1 (2-iodo-4-methoxyphenyl)methanol 
• 54435-09-5 2-iodo-4-methoxybenzoic acid 
• 260558-14-3 3-iodo-4-methylanisole 

Downstream Products

• 956103-50-7 [4-(2-iodo-4-methoxyphenyl)-1-butynyl](triisopropyl)silane 
• 1206189-87-8 2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2'-iodo-4'-methoxybenzyl)-(2R,5S)-pyrazine 
• 332124-27-3 (2S,5S)-tert-butyl-5-(2'-iodo-4'-methoxybenzyl)-2-tert-butyl-3-methyl-4-oxoimidazolidine-1-carboxylate 

Relevant academic research and scientific papers

CuSO4-Catalyzed Tandem C(sp3)-H Insertion Cyclization of Toluenes with Isonitriles to Form Indoles

A CuSO4-catalyzed tandem benzylic C-H insertion cyclization of toluene derivatives and isonitriles is described. The naturally abundant salt CuSO4 serves as a low-cost ligand-free redox catalyst. This reaction provides a practical mo

Access to chiral tetrahydrofluorenes through a palladium-catalyzed enantioselective tandem intramolecular Heck/Tsuji-Trost reaction

A palladium-catalyzed enantioselective coupling of 2,5-cyclohexadienyl-substituted aryl iodides and carbon or heteroatom nucleophiles is described. The reaction proceeded via a tandem asymmetric Heck insertion and Tsuji-Trost allylation, enabling the rapi

Phenanthroline- tBuOK Promoted Intramolecular C-H Arylation of Indoles with ArI under Transition-Metal-Free Conditions

The first example of phenanthroline-tBuOK promoted intramolecular radical C-H arylation of N-(2-iodobenzyl)indoles without involvement of transition metals has been developed. A variety of substituted 6H-isoindolo [2, 1-a] indoles were prepared by a simple and efficient intramolecular cyclization using 1,10-phenanthroline in the presence of potassium tert-butoxide and chlorobenzene. This strategy provides a fast and versatile access to isoindolo[2,1-a]indole derivatives for the synthesis of pharmaceuticals and organic electroluminescent (EL) materials.

NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS

Iodylbenzene derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are used as precursors in aromatic nucleophilic substitution reactions. The iodyl group (IO2) is regiospecifically substituted by nucleophilic fluoride to provide the corresponding fluoroaryl derivatives. No-carrier-added [F-18] fluoride ion derived from anhydrous [F- 18]KF/Kryptofix, [F-18]CsF or a quaternary ammonium fluoride (e.g., Me4NF, Et4NF, n-Bu4NF, (PhCH2)4NF) exclusively substitutes the iodyl moiety in these derivatives and provides high specific activity F- 18 labeled fluoroaryl analogs. Iodyl derivatives of a benzothiazole analog and 6-iodyl-L-dopa derivatives have been synthesized as precursors and have been used in the preparation of no-carrier-added [F-18]fluorobenzothiazole as well as 6-[F-18]fluoro-L-dopa.

A convenient route to 2-hydroxy- and 2,15-dihydroxyhexahelicene

2-Hydroxy- and 2,15-dihydroxyhexahelicene were synthesised from simple benzene and naphthalene building blocks by intramolecular Co1- or Ni0-catalysed [2+2+2] cycloisomerisation of CH3O- substituted aromatic triynes. This