260558-14-3

Upstream product

• 104-93-8 p-methylanizole 
• 7790-99-0 Iodine monochloride 
• 64-19-7 acetic acid 
• 17484-36-5 4-Methyl-3-nitroanisole 
• 50868-72-9 5-methoxy-o-toluidine 

Downstream Products

• 64297-78-5 3-iodosyl-4-methyl-anisole 
• 332124-25-1 1-(bromomethyl)-2-iodo-4-methoxybenzene 
• 1188412-63-6 (S)-2-(5-methoxy-2-methyl-phenyl)-1-methyl-ethylamine 
• 1638139-86-2 1-methoxy-2-(4-methoxybenzyl)-4-methyl-3-(1-phenylvinyl)benzene 
• 1188412-60-3 (2R)-1-(5-methoxy-2-methylphenyl)propan-2-ol 

Relevant academic research and scientific papers

NOVEL TYROSINE KINASE INHIBITORS

Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.

A convenient route to 2-hydroxy- and 2,15-dihydroxyhexahelicene

2-Hydroxy- and 2,15-dihydroxyhexahelicene were synthesised from simple benzene and naphthalene building blocks by intramolecular Co1- or Ni0-catalysed [2+2+2] cycloisomerisation of CH3O- substituted aromatic triynes. This

Direct and regioselective iodination and bromination of benzene, naphthalene and other activated aromatic compounds using iodine and bromine

Direct and regioselective iodination and bromination of benzene, naphthalene and other activated aromatic compounds with iodine and bromine or their sodium salts proceed well in the presence of Fe(NO3) 3·1.5N2O4/charcoal in CH 2Cl2 at room temperature.

Palladium-catalyzed sequential alkylation - Alkenylation reactions and their application to the synthesis of fused aromatic rings

The synthesis of fused aromatic carbocycles from aryl iodides and difunctional acceptors is outlined. This methodology is based on a palladium-catalyzed aromatic substitution followed by an intramolecular Heck sequence. Under the optimized conditions (Pd(OAc)2 (10 mol %), tri-2-furylphosphine (20-30 mol %), norbornene (2 equiv), Cs2CO3 (2 equiv), CH3CN, reflux), bromoenoates react with aryl iodides bearing numerous substituents (F, Cl, CF3, Me, etc.). The expanded description of our initial work as well as the use of polysubstituted aryl iodides is described.