33213-50-2

Upstream product

• 50-00-0 formaldehyd 
• 27250-45-9 (6R)-3-methyl-5ξ,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 24689-52-9 2,2,2-trichloroethyl 7β-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide 
• 24647-47-0 2,2,2-Trichloroethyl (6R,7R)-3-methyl-<(phenoxyacetyl)amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate 

Downstream Products

• 49823-73-6 (6'R)-3'-methyl-5'ξ,8'-dioxo-7't-(2-phenoxy-acetylamino)-(6'rH)-5'λ⁴-spiro[cyclopropane-1,4'-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene)]-2'-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 33277-64-4 (6R)-3,4-dimethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 33277-66-6 (6R)-3-methyl-4-methylene-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 33277-65-5 (6R)-4c-bromo-4t-bromomethyl-3-methyl-5ξ,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 33277-63-3 (6R)-3,4c-dimethyl-5ξ,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 33213-51-3 (6R)-3,4t-dimethyl-5ξ,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 33126-07-7 (6R)-3-methyl-4-((Z)-1-methyl-1H-tetrazol-5-ylsulfanylmethylene)-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 33126-06-6 (6R)-4-(Z)-ethylsulfanylmethylene-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 54752-16-8 (6'R)-8'-oxo-3'-methyl-7't-(2-phenoxy-acetylamino)-(6'rH)-spiro[cyclopropane-1,4'-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene)]-2'-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 31932-97-5 (6R)-3ξ-methyl-4-methylene-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2ξ-carboxylic acid 
• 31937-83-4 (6R)-4-(Z)-ethylsulfanylmethylene-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 33126-09-9 (6R)-7t-amino-4-((Z)-4-bromo-phenylsulfanylmethylene)-3-methyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 31937-84-5 (6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-4-(Z)-pyrimidin-2-ylsulfanylmethylene-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 31981-21-2 (6R)-4-((Z)-4-bromo-phenylsulfanylmethylene)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Relevant academic research and scientific papers

SYNTHESIS AND 1,3-DIPOLAR CYCLOADDITIONS OF 2-METHYLENECEPHALOSPORINS

Cephalosporin R- and S-sulphoxides were prepared.The S-sulphoxides gave Mannich-reaction resulting in the formation of 2-methylenecephalosporins.These electrom-deficient dienes underwent 1,3-dipolar cycloadditions with diazoalkanes in a chemo- and regiosp