332178-62-8Relevant academic research and scientific papers
Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists
Griffith, David A.,Hargrove, Diane M.,Maurer, Tristan S.,Blum, Charles A.,De Lombaert, Stéphane,Inthavongsay, John K.,Klade, Lee E.,MacK, Christine M.,Rose, Colin R.,Sanders, Martin J.,Carpino, Philip A.
, p. 2641 - 2645 (2011/06/20)
A novel series of pyrazolo[1,5-a]pyrimidine derivatives was synthesized and evaluated as NPY Y1R antagonists. High binding affinity and selectivity were achieved with C3 trisubstituted aryl groups and C7 substituted 2-(tetrahydro-2H-pyran-4-ylamino)ethyla
Certain alkylene diamine-substituted pyrazlo (1,5-a)-1,5-pyrimidines and pyrazolo (1,5-a) 1,3,5-triazines
-
, (2008/06/13)
Disclosed are compounds of the formula: where R1, R2, R3, R4, R5, R6, and X are defined herein. These compounds are selective modulators of NPY1 receptors. These compounds are useful in the
