430-69-3

Upstream product

• 454-31-9 ethyl difluoroacetate 

Downstream Products

• 431-04-9 (rac)-1,1-difluoro-2-propanol 
• 37759-73-2 (E)-4,4-difluoro-but-2-enoic acid 
• 107699-65-0 N-(2,2-difluoroethylidene) 1-phenyl ethylamine 
• 332178-62-8 N-[3-(2,6-dichloro-4-methoxy-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-N'-(2,2-difluoro-ethyl)-ethane-1,2-diamine 
• 1035265-54-3 2-(4-chlorophenyl)-5-{4-[1-(2,2-difluoroethyl)azetidin-3-yloxy]-3-methoxyphenyl}-5H-thiazolo[5,4-c]pyridin-4-one 

Relevant academic research and scientific papers

Manufacturing method of [alpha],[alpha]-difluoroacetaldehyde

The objective of the present invention is to provide a manufacturing method of [alpha],[alpha]-difluoroacetaldehyde capable of being industrially easily implemented without special equipment. The manufacturing method of [alpha],[alpha]-difluoroacetaldehyde or hydrate thereof or hemiacetal is characterized in that difluoroacetate represented by the general formula CF2HCOOR1[R1 represents an alkyl group or substituted alkyl group] reacts with tetrahydridoborate which serves as a hydride reducing agent in the presence of a protic solvent and alkali.