332181-58-5Relevant academic research and scientific papers
4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists
Pinard, Emmanuel,Alanine, Alexander,Bourson, Anne,Buettelmann, Bernd,Heitz, Marie-Paule,Mutel Ramanjit Gill, Vincent,Trube, Gerhard,Wyler, Rene
, p. 2615 - 2619 (2007/10/03)
Screening of the Roche compound library led to the identification of 4-aminoquinoline 4 as structurally novel NR1/2B subtype selective NMDA receptor antagonist. The SAR which was developed in this series resulted in the discovery of highly potent and in vivo active blockers.
Quinolin-4-yl derivatives
-
, (2008/06/13)
Phenyl substituted quinolin 4-yl derivatives and pharmaceutical compositions with activity as NMDA-receptor subtype selective blockers. The compounds of the invention modulate neuronal activity and plasticity.
