33229-30-0

Basic information

• Product Name: (4-chloro-benzimidoylaminooxy)-butenedioic acid dimethyl ester
• Synonyms: (4-chloro-benzimidoylaminooxy)-butenedioic acid dimethyl ester
• CAS NO: 33229-30-0
• Molecular Weight: 312.71
• Mol File: 33229-30-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (4-chloro-benzimidoylaminooxy)-butenedioic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4-chloro-benzimidoylaminooxy)-butenedioic acid dimethyl ester(33229-30-0)
• EPA Substance Registry System: (4-chloro-benzimidoylaminooxy)-butenedioic acid dimethyl ester(33229-30-0)

Safety Data

• Hazardous Substances Data: 33229-30-0(Hazardous Substances Data)

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 5033-28-3 4-chlorobenzamidoxime 
• 762-42-5 dimethyl acetylenedicarboxylate 

Downstream Products

• 70274-16-7 [3-(4-chloro-phenyl)-5-oxo-4,5-dihydro-[1,2,4]oxadiazin-6-ylidene]-acetic acid methyl ester 
• 33229-28-6 3-(4-chloro-phenyl)-5-methoxycarbonylmethyl-2⁽⁴⁾,5-dihydro-[1,2,4]oxadiazole-5-carboxylic acid methyl ester 

Relevant articles and documents

Pharmacophore requirements for HIV-1 reverse transcriptase inhibitors that selectively “Freeze” the pre-translocated complex during the polymerization catalytic cycle

Reverse transcriptase (RT) is responsible for replicating the HIV-1 genome and is a validated therapeutic target for the treatment of HIV infections. During each cycle of the RT-catalyzed DNA polymerization process, inorganic pyrophosphate is released as the by-product of nucleotide incorporation. Small molecules were identified that act as bioisosteres of pyrophosphate and can selectively freeze the catalytic cycle of HIV-1 RT at the pre-translocated stage of the DNA- or RNA-template-primer-enzyme complex.

Synthesis of 1,2,4-oxadiazines and their rearrangement to pyrimidines

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