3323-03-3

Basic information

• Product Name: 3-(Morpholinomethyl)-2-phenylimidazo[1,2-a]pyridine
• Synonyms: 3-(Morpholinomethyl)-2-phenylimidazo[1,2-a]pyridine
• CAS NO: 3323-03-3
• Molecular Formula: C₁₈H₁₉N₃O
• Molecular Weight: 0
• Mol File: 3323-03-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.21g/cm³
• Refractive Index: 1.647
• CAS DataBase Reference: 3-(Morpholinomethyl)-2-phenylimidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Morpholinomethyl)-2-phenylimidazo[1,2-a]pyridine(3323-03-3)
• EPA Substance Registry System: 3-(Morpholinomethyl)-2-phenylimidazo[1,2-a]pyridine(3323-03-3)

Safety Data

• Hazardous Substances Data: 3323-03-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H19N3O/c1-2-6-15(7-3-1)18-16(14-20-10-12-22-13-11-20)21-9-5-4-8-17(21)19-18/h1-9H,10-14H2

Upstream product

• 110-91-8 morpholine 
• 50-00-0 formaldehyd 
• 4105-21-9 2-phenylimidazo[1,2-a]pyridine 
• 504-29-0 2-aminopyridine 
• 75-09-2 dichloromethane 
• 70-11-1 α-bromoacetophenone 
• 298-12-4 Glyoxilic acid 
• 532-27-4 1-chloroacetophenone 
• 7529-22-8 4-methylmorpholine N-oxide 

Relevant articles and documents

Four-component synthesis of 3-aminomethylated imidazoheterocycles in EtOH under catalyst-free, oxidant-free and mild conditions

With green ethanol as the sole solvent, various 3-aminomethylated imidazoheterocycles were efficiently synthesized in one step through a four-component reaction of equimolar cheap and commercially available reactants at ambient temperature under metal-free, oxidant-free and mild conditions.

Discovery of new leads against Mycobacterium tuberculosis using scaffold hopping and shape based similarity

BM212 [1,5-diaryl-2-methyl-3-(4-methylpiperazin-1-yl)-methyl-pyrrole] is a pyrrole derivative with strong inhibitory activity against drug resistant Mycobacterium tuberculosis and mycobacteria residing in macrophages. However, it was not pursued because o

Oxidative Cross-Coupling of sp3- and sp2-Hybridized C-H Bonds: Vanadium-Catalyzed Aminomethylation of Imidazo[1,2-a]pyridines

The vanadium-catalyzed oxidative coupling of substituted 2-arylimidiazo[1,2-a]pyridines to N-methylmorpholine oxide, which acts as both a coupling partner and an oxidant, has been achieved. This reaction was applied to various substituted imidiazo[1,2-a]pyridine and indole substrates, resulting in yields as high as 90%. Mechanistic investigations indicate that the reaction may proceed via a Mannich-type process. This work demonstrates how oxidative aminomethylation can be used as a useful method to introduce tertiary amines into heterocycles, thus providing an alternative method for conventional Mannich-type reactions.