33237-20-6

Usage

Uses

Used in Pharmaceutical Industry:
2,4-DIAMINO-6-(4-PYRIDYL)-S-TRIAZINE is utilized as a building block in the synthesis of pharmaceuticals due to its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-DIAMINO-6-(4-PYRIDYL)-S-TRIAZINE serves as a key intermediate in the creation of agrochemicals, which are essential for enhancing crop protection and yield.
Used in Dye and Pigment Production:
2,4-DIAMINO-6-(4-PYRIDYL)-S-TRIAZINE is employed as an intermediate in the production of dyes and pigments, contributing to the coloration and enhancement of various products in different industries.
Used in Specialty Chemicals:
2,4-DIAMINO-6-(4-PYRIDYL)-S-TRIAZINE also finds application in the realm of specialty chemicals, where it is used to produce compounds with specific properties tailored for unique applications across various industries.

InChI:InChI=1/C8H8N6/c9-7-12-6(13-8(10)14-7)5-1-3-11-4-2-5/h1-4H,(H4,9,10,12,13,14)

Upstream product

• 100-48-1 pyridine-4-carbonitrile 
• 127099-85-8 N-Cyanoguanidine 
• 127099-85-8 dicyandiamide 

Relevant academic research and scientific papers

Triazine Based MOFs with Abundant N Sites for Selective Nitrobenzene Detection

High sensitivity and selectivity detection of nitrobenzene based on luminescence technology requires high density of functional sites. Due to the abundant functional N sites and good solubility in solvents, triazine derivative ligands are potential to construct frameworks as luminescence detection agent. Herein, a Pt3O4 topology Zn-MOF (FJU-120) based on 2-amino-4,6-bis(4-pyridine)-1,3,5-triazine(DAPT) and 1,3,5-Tris-(p-carboxyphenyl)benzene (H3BTB) as dual-ligands was synthesized for selective detection of nitrobenzene. FJU-120 crystallizes in the cubic system and Pm (Formula presented.) n space group with a=27.5191(9), b=27.5191(9), c=27.5191(9) ?, β=90°, V=20840(2) ?3, Z=90, Mr=448.72, Dc=0.429 g/cm3, F(000)=2736. FJU-120 shows selective fluorescence quenching behavior with nitrobenzene existing, and the corresponding (Formula presented.) constant is 1124.65 L mol?1. This work reports a new potential crystalline porous material for toxic organic molecular fluorescence detection.

Selective CO2 adsorption and theoretical simulation of a stable Co(ii)-based metal-organic framework with tunable crystal size

A three-fold interpenetrated metal-organic framework [Co2(OBA)4(PTD)·3DMF·CH3CH2OH·5H2O]n (1) has been synthesized by utilizing 4,4′-oxybis(benzoic acid) (H2OBA) as the linker, 6-(pyridin-4-yl)-1,3,5-triazine-2,4-diamine (PTD) as the ligand, and CoCl2·6H2O via solvothermal method. Compound 1 exhibits not only a high uptake capacity for CO2 molecules with an estimated high sorption heat (50.6 kJ mol?1 at zero loading), but also a significant selective adsorption of CO2 over CH4, which may be ascribed to the presence of proper-sized pores with high polarity, amine groups and triazine rings of PTD linker decorating the pores. Meanwhile, the Grand Canonical Monte Carlo (GCMC) simulations of CO2 adsorption of compound 1 demonstrate that CO2 molecules are preferentially adsorbed around the PTD ligands. Furthermore, complex 1 displays a relatively high adsorption capacity of H2 (101.7 cm3 g?1 at 1 bar) under 77 K.

A new set of Cd(II)-coordination polymers with mixed ligands of dicarboxylate and pyridyl substituted diaminotriazine: Selective sorption towards CO2 and cationic dyes

On the basis of a mixed ligand system of L(NH2)2 (6-(pyridin-4-yl)-1,3,5-triazine-2,4-diamine) and dicarboxylic acids, three new Cd(ii) coordination polymers viz. {[Cd0.5(tdc)0.5(L(NH2)2)0.5(H2O)]·DMF·H2O}n (1), {[Cd0.5(bdc)0.5(L(NH2)2)(H2O)]·DMF·H2O}n (2), and {[Cd(ipa)(L(NH2)2)(DMF)]·H2O}n (3) (tdcH2 = thiophene-2,5-dicarboxylic acid, bdcH2 = benzene-1,4-dicarboxylic acid, ipaH2 = benzene-1,3-dicarboxylic acid) were synthesized under diverse reaction conditions and characterized by single crystal X-ray diffraction, PXRD, elemental analysis, IR spectroscopy and TGA. While 1 and 2 revealed 1D chain structures, 3 acquired a 2D square net structural arrangement. Gas adsorption measurements of the desolvated framework 3 showed a moderate uptake of CO2 under ambient conditions with good selectivity over N2 and CH4. The solid state luminescence properties were studied for all three coordination polymers. Moreover, a dye adsorption study on 3 exhibited selective adsorption towards a cationic dye.

A stable luminescent zinc-organic framework as a dual-sensor toward Cu2+ and Cr2O72-, and excellent platform-encapsulated Ln3+ for systematic color tuning and white-light emission

A stable, luminescent zinc-organic framework (MOF)[Zn(OBA)2(PTD)·2DMF·2H2O]n (1; H2OBA = 4,4′-oxybis(benzoic acid), PTD = 6-(pyridin-4-yl)-1,3,5-triazine-2,4-diamine) was synthesized using a V-shaped, carboxylate H2OBA ligand containing conjugated π-moieties and a rigidly auxiliary N-rich PTD ligand, which displayed a 3D, three-fold interpenetrated framework with highly thermal and chemical stabilities. Complex 1 exhibited a strong luminescent emission, and could selectively detect Cu2+ and Cr2O72-, making it a potential dual functional chemosensor. Furthermore, the systematic explorations of lanthanide(iii) cation encapsulation for compound 1 suggested that Ln3+-doped compounds are good candidates as color-tunable and barcoded materials. Moreover, by soaking this as-synthesized MOF (50 mg) into a 10 mL DMF solution containing 5 × 10-5 mmol Ln3+ ions (Eu3+/Tb3+, 13/7), the white light-emission of the Ln3+-doped compound 1 was realized with the Commission Internationale de L'Eclairage coordinates (0.3095, 0.2945). The quantum yield of this white light-emitting sample is 29%, which is higher than those of most reported doped MOFs with white light-emission. Furthermore, compound 1 exhibited a selective gas capture for CO2 over CH4.

2,4,6-trisubstituted-1,3,5-s-triazine compound and preparation and application thereof

The invention provides a 2,4,6-trisubstituted-1,3,5-s-triazine compound as well as preparation and application thereof, and biguanide or dimethyl biguanide hydrochloride is used as an initial raw material to react with a cyano compound under an alkaline condition to prepare the 2,4,6-trisubstituted-1,3,5-s-triazine compound. The invention provides a simple and convenient synthetic method of a 2,4,6-trisubstituted-1,3,5-s-triazine compound, and the compound provided by the invention can be applied to preparation of an anti-myelogenous leukemia medicine, namely an enasidenib medicine. Compared with the prior art, the method for preparing the enasidenib has the advantages that two-step reaction is reduced, the use of a halogenating reagent is avoided, and the method is a green and environment-friendly chemical process. The structural formula I is shown in the specification.

Synthesis of O2-and N3-(2-phosphonomethoxy)ethyl derivatives of 6-phenyl- and 6-pyridinyl-5-azacytosine

A series of hydrolytically stable O2- and N3-(2- phosphonomethoxy)- ethyl (PME) derivatives of 6-phenyl, pyridin-2, -3 and -4-yl-5-azacytosines was prepared by their alkylation with diisopropyl (2-chloroethoxy)methylphosphonate followed by the deprotection. No antitumor or antiviral activity was found except for 6-(pyridin-4-yl)-1,3,5-triazine-2,4- diamine (13d) which exhibited slight activity against feline herpesvirus in CrFK cell cultures with IC50 = 6.7 μg/mL.

Green synthesis and self-association of 2,4-diamino-1,3,5-triazine derivatives

2,4-Diamino-1,3,5-triazines have been prepared by reaction of dicyandiamide with nitriles under microwave irradiation, a method that can be considered as a green procedure due to the reduction in the use of solvents during synthesis and purification, the short reaction time and the simplicity of the procedure. The structures have been confirmed in solution by NMR spectroscopy. Variable temperature experiments have been used to calculate the free energy of activation for rotation about the amino-triazine bond. The crystal structures of three 2,4-diamino-6-R-1,3,5-triazine derivatives (3a: R = phenyl, 3i: R = 1-piperidino and 3g: R = 1-phenylpyrazol-3-yl) have been determined by X-ray analysis. The N-H...N interactions change from structure to structure, resulting in a variation from pseudo-honeycomb networks to corrugated rosette layers.