33238-22-1Relevant academic research and scientific papers
Palladium/Copper-Catalyzed Denitrogenative Alkylidenation and ortho-Alkynylation Reaction of 1,2,3-Benzotriazin-4(3 H)-ones
Hari Balakrishnan, Madasamy,Mannathan, Subramaniyan
supporting information, p. 542 - 546 (2020/02/04)
An efficient palladium-catalyzed approach to access various functionalized (Z)-3-benzylidene-isoindoline-1-ones and (Z)-3-benzylidene(imino)isobenzofuranones via a denitrogenative tandem alkynylation/cyclization reaction of 1,2,3-benzotriazin-4(3H)-ones w
A ligand-free approach to substituted (Z)-3-methyleneisoindolin-1-ones via Cu (I) catalyzed regio- and stereo-selective assembly of 2-iodo benzamide and terminal alkyne
De, Rimpa,Bera, Mrinal K.
supporting information, p. 1780 - 1789 (2020/05/29)
A ligand-free and cost-effective synthesis of substituted 3-methyleneisoindolin -1-ones from 2-iodobenzamide and terminal alkyne under copper (I)-catalyzed condition was accomplished. The reaction affords excellent yield of the product at a relatively low
Preparation method of 3-methylene isoindole-1-one derivatives
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Paragraph 0118; 0119; 0120; 0121; 0122; 0123; 0124; 0125, (2017/07/20)
The invention relates to a preparation method of 3-methylene isoindole-1-one derivatives. The preparation method comprises the following steps: an N-substituted 2-chlorobenzamide derivative in formula (1), alkyne-terminated compounds in formula (2) and ni
An Easy-to-Machine Electrochemical Flow Microreactor: Efficient Synthesis of Isoindolinone and Flow Functionalization
Folgueiras-Amador, Ana A.,Philipps, Kai,Guilbaud, Sébastien,Poelakker, Jarno,Wirth, Thomas
, p. 15446 - 15450 (2017/11/10)
Flow electrochemistry is an efficient methodology to generate radical intermediates. An electrochemical flow microreactor has been designed and manufactured to improve the efficiency of electrochemical flow reactions. With this device only little or no supporting electrolytes are needed, making processes less costly and enabling easier purification. This is demonstrated by the facile synthesis of amidyl radicals used in intramolecular hydroaminations to produce isoindolinones. The combination with inline mass spectrometry facilitates a much easier combination of chemical steps in a single flow process.
A Cu-catalysed synthesis of substituted 3-methyleneisoindolin-1-one
Gogoi, Anupal,Guin, Srimanta,Rout, Saroj K.,Majji, Ganesh,Patel, Bhisma K.
, p. 59902 - 59907 (2015/02/19)
A Cu(I)-catalysed synthesis of substituted 3-methyleneisoindolin-1-ones using alkynyl acids as an alkyne source has been developed. The reaction involves the decarboxylative cross-coupling of 2-halobenzamides with aryl alkynyl acids, followed by 5-exo-dig
Copper(II)-catalyzed tandem synthesis of substituted 3-methyleneisoindolin- 1-ones
Pan, Jie,Xu, Zhen,Zeng, Runsheng,Zou, Jianping
supporting information, p. 1022 - 1026 (2013/09/02)
An efficient strategy for the synthesis of a variety of 3-methyleneisoindolin-1-ones has been developed. The reaction proceeded from coupling of 2-iodobenzamides (or 2-bromobenzamides) and terminal alkynes via Cu(OAc)2·H2O/2,2′-biimi
