33252-54-9Relevant academic research and scientific papers
Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief
Gado, Francesca,Di Cesare Mannelli, Lorenzo,Lucarini, Elena,Bertini, Simone,Cappelli, Elena,Digiacomo, Maria,Stevenson, Lesley A.,Macchia, Marco,Tuccinardi, Tiziano,Ghelardini, Carla,Pertwee, Roger G.,Manera, Clementina
, p. 276 - 287 (2018/07/21)
The direct activation of cannabinoid receptors (CBRs) results in several beneficial effects; therefore several CBRs ligands have been synthesized and tested in vitro and in vivo. However, none of them reached an advanced phase of clinical development due
FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS
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Page 213-214, (2008/06/13)
The present invention is directed to compounds represented by the following structural formula, Formula I: wherein (a) X is selected from the group consisting of a single bond, O, S. S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of C, O, S, NH and a single bond; (d) E is C(R3) (R4)A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamidek, sulfonamide and acylsulfonamide; (e) B is selected from the group consisting of S, O, C, and N; (f) Z is selected from the group consisting of N and C; with the proviso that when B is C then Z is N.
Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
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, (2008/06/13)
Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of the formula: where the formula variables are as defined herein that advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described.
