33254-88-5Relevant academic research and scientific papers
A 5 - (N, N - dibenzyl amino) acetyl salicylic amide preparation method
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Paragraph 0027; 0031; 0036; 0042; 0043; 0049-0050; 0056-0057, (2017/08/25)
The invention relates to a preparation method for 5-(N, N-dibenzylamino)acetylsalicylamide. The method includes: adding salicylamide and chloroacetyl chloride into a container to carry out reaction according to a mole ratio of 1: 2.5-5.5, using an ionic liquid as the solvent, with the mole ratio of the ionic liquid to salicylamide being 5-10:1, carrying out reaction at 35-55DEG C under atmospheric pressure, then at the end of the reaction, taking an organic solvent to perform extraction to obtain 5-chloracetylsalicylamide, adding the prepared 5-chloracetylsalicylamide and dibenzylamine into a mixed solution of water and methanol, with the volume ratio of methanol to water being 2-4:1, carrying out heating reaction at 50-70DEG C for 2-4h, with 5-chloracetylsalicylamide and dibenzylamine being in a mole ratio of 1:1.0-1.2, at the end of the reaction, conducting vacuum distillation to remove the solvent, and performing recrystallization to obtain 5-(N, N-dibenzylamino)acetylsalicylamide. The preparation method provided by the invention has the characteristics of low production cost, short synthesis step, high yield, and small environmental pollution.
