33257-75-9

Upstream product

• 33257-84-0 4-(p-acetoxyphenyl)-7-methoxy-3-phenylcoumarin 
• 33257-86-2 (2-hydroxy-4-methoxyphenyl)-(4-hydroxyphenyl)-methanone 
• 150-19-6 O-methylresorcine 
• 99-96-7 4-hydroxy-benzoic acid 
• 108-46-3 recorcinol 
• 1470-79-7 2,4,4'-trihydroxy-benzophenone 
• 1450604-21-3 4-(7-acetoxy-2-oxo-3-phenyl-2H-chromen-4-yl)phenyl acetate 

Downstream Products

• 1450604-34-8 7-(2-(pyrrolidin-1-yl)ethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one 
• 1450604-35-9 7-(2-(piperidin-1-yl)ethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one 
• 1450604-23-5 7-(2-morpholinoethoxy)-4-(4-(2-morpholinoethoxy)phenyl)-3-phenyl-2H-chromen-2-one 
• 1450604-31-5 7-(2-(pyrrolidin-1-yl)ethoxy)-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-3-phenyl-2Hchromen-2-one 
• 1450604-32-6 7-(2-(piperidin-1-yl)ethoxy)-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-phenyl-2Hchromen-2-one 
• 1450604-33-7 7-(2-(diethylamino)ethoxy)-4-(4-(2-(diethylamino)ethoxy)phenyl)-3-phenyl-2Hchromen-2-one 
• 1450604-25-7 7-(2-morpholinoethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one 
• 1450604-22-4 7-(2-bromoethoxy)-4-(4-(2-bromoethoxy)phenyl)-3-phenyl-2H-chromen-2-one 
• 1450604-24-6 7-(2-bromoethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one 

Relevant academic research and scientific papers

Design, synthesis, and anti-tumor activities of novel triphenylethylene- coumarin hybrids, and their interactions with Ct-DNA

Novel triphenylethylene-coumarin hybrid derivatives containing different amounts of amino side chains were designed and synthesized in good yields under microwave radiation. The derivatives 5b-d which possessed two amino side chains (except morpholinyl) showed a broad-spectrum and good anti-proliferative activity against five tumor cells and low cytotoxicity in osteoblast. UV-vis, fluorescence, and circular dichroism (CD) spectroscopies and thermal denaturation exhibited that compounds 10c, 5c, and 13c bearing amino side chain (except morpholinyl) on 4-phenyl had significant interactions with Ct-DNA by the intercalative mode of binding. Structure-activity relationships (SARs) analysis suggested that the amino alkyl chain would play an important role both in the compounds against tumor cells proliferation and their interactions with DNA.