3326-82-7

Upstream product

• 44805-37-0 L-methioninato 
• 80937-33-3 oxygen 
• 63-68-3 L-methionine 
• 7758-99-8 copper(II) sulfate 
• 59-51-8 DL-methionine 

Relevant academic research and scientific papers

Copper monooxygenase models. Aromatic hydroxylation by a dinuclear copper(I) complex containing methionine sulfur ligands

A dinuclear copper(I) complex 1 containing a bis(imine) ligand derived from the condensation between benzene-1,3-dicarbaldehyde and two molecules of L-methionine has been prepared. When this compound reacts with dioxygen a partial aromatic hydroxylation of the ligand occurs, giving a dinuclear μ-phenoxoμ-hydro-dicopper(II) complex 2, together with simple copper oxidation products. Definitive evidence of the monooxygenase activity of the present sulfur-containing model system results from the crystallographic characterisation of the dinuclear copper(II) complex 3 of the hydroxylated dicarbaldehyde, [Cu2{C6H3(CHO)2O}-(ClO 4)2], which forms upon hydrolysis of the imine groups of 2. In this complex two deprotonated 1,3-diformylphenoxide ligands bind two copper(II) ions, with di-μ-phenoxo bridges. Each copper is essentially square pyramidal, with a basal O4 donor set, including two phenoxide and two carbonyl oxygen atoms from two 2-hydroxybenzene-1,3-dicarbaldehyde ligands. Two perchlorate oxygen atoms are bound in axial positions on opposite sides of the Cu2O6 plane. A minor fraction (15-20%) of 2 contains 5-oxygenated methionine residues. However, oxygenation at sulfur is a secondary process, resulting from the reaction of H2O2, formed according to the simple copper(I) oxidation pathway, and the dinuclear copper(II) complex 2.

ENERGY-EFFICIENT SOLVENT-FREE METHOD FOR PRODUCING METAL CHELATES

The invention relates to a method for producing, amongst other things, amino-acid and/or hydroxycarboxylic-acid metal chelates, a solvent-free mixture of at least one metal oxide, metal hydroxide, metal carbonate or oxalate, and the solid organic acid is subjected to intensive mechanical stress. According to the invention, this is done in that the reaction partners are introduced in particle form into a fluid stream of a fluid-bed countercurrent mill operating without grinding elements, wherein mechanical activation of at least one of the reaction partners is effected by collision processes within a reaction chamber formed in a region of the fluid stream, and a solid body reaction to form the metal chelate is triggered. The novel method operates very energy-efficiently and with a high specific yield. It leads to a product having compact particles in the small, single-digit micrometer range having a comparatively narrow particle size distribution and a large surface. The product is homogenous and very pure. Thermal loading or decomposition of the organic chelate ligands, in particular of the amino acids, is likewise avoided, as are contaminants from milling and grinding element abrasion.

METHOD FOR THE PRODUCTION OF METAL CARBOXYLATES AND THE METAL AMINOATE OR METAL HYDROXY ANALOGUE METHIONATE DERIVATIVES THEREOF, AND USE OF SAME AS GROWTH PROMOTERS IN ANIMAL FEED

A method of production of metal carboxylates and of their metal carboxylate-aminoate or metal carboxylate-methioninate hydroxy analog derivatives, and their use as growth promoters in animal nutrition. It comprises mixing stoichiometric quantities of formic or butyric acid and oxide and of the dry basic salt of divalent metal, the oxide or hydroxide of Zn2+ or Cu2+, to give an exothermic reaction, without addiction of solvents, giving rise to a dry carboxylate of divalent metal that is easy to use. It also describes the use of a stage of mixing with metal aminoates or hydroxy analogs of methionine in the process, for forming either a carboxylate-aminoate of divalent metal or a carboxylate-methioninate hydroxy analog of divalent metal, products that are finally obtained in a dry form that is easy to use. Finally it describes the use of the compounds that can be obtained in the feeding of monogastric animals for improving the productivity, the bioavailability of the metals, and achieve a reduction of their emission to the environment, owing to the growth-promoting effect that they all display.

METAL ION COORDINATION IN POLYCRYSTALLINE COPPER(II) COMPLEXES OF α-AMINO ACIDS. VISIBLE AND INFRAERD SPECTRAL STUDIES.

Investigation of 30 polycrystalline copper(II) complexes of α-amino acids encountered in proteins was reported.From comparisons of the diffuse reflectance spectra and the carboxylate streching vibrations of the compounds of known crystal structure with th