33284-02-5

Basic information

• Product Name: 2-amino-N-[2-(1H-indol-3-yl)ethyl]benzamide
• Synonyms: benzamide, 2-amino-N-[2-(1H-indol-3-yl)ethyl]-; N1-[2-(1H-indol-3-yl)ethyl]-2-aminobenzamide
• CAS NO: 33284-02-5
• Molecular Formula: C₁₇H₁₇N₃O
• Molecular Weight: 279.3364
• Mol File: 33284-02-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 585.8°C at 760 mmHg
• Flash Point: 308.1°C
• Density: 1.259g/cm³
• Vapor Pressure: 1.05E-13mmHg at 25°C
• Refractive Index: 1.698
• CAS DataBase Reference: 2-amino-N-[2-(1H-indol-3-yl)ethyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-N-[2-(1H-indol-3-yl)ethyl]benzamide(33284-02-5)
• EPA Substance Registry System: 2-amino-N-[2-(1H-indol-3-yl)ethyl]benzamide(33284-02-5)

Safety Data

• Hazardous Substances Data: 33284-02-5(Hazardous Substances Data)

Usage

Chemical compound

2-amino-N-[2-(1H-indol-3-yl)ethyl]benzamide

Also known as

N-(2-aminophenyl)-2-(1H-indol-3-yl)ethylamine
Benzamide derivative with an ethyl chain attached to the indole ring
Potential applications in pharmaceutical research
Study of biological processes related to the indole ring, such as serotonin and melatonin production
Relevance in the development of new drugs targeting serotonin receptors
Potential building block for the synthesis of other bioactive compounds

Upstream product

• 61-54-1 tryptamine 
• 201230-82-2 carbon monoxide 
• 615-43-0 2-iodophenylamine 
• 118-92-3 anthranilic acid 
• 118-48-9 isatoic anhydride 

Downstream Products

• 1616559-69-3 N-(2-(1H-indol-3-yl)ethyl)-2-trifluoroacetamidobenzamide 
• 1616559-67-1 N-(2-(1H-indol-3-yl)ethyl)-2-propionamidobenzamide 
• 84-26-4 rutaecarpine 
• 55786-24-8 7,8-Dehydrorutecarpine 
• 518-17-2 evodiamine 
• 68353-23-1 14-formyl-13b,14-dihydrorutaecarpine 
• 95274-61-6 N-[2-(1H-Indol-3-yl)-ethyl]-2-[methyl-(2,2,2-trifluoro-acetyl)-amino]-benzamide 
• 95274-60-5 isoevodiamine 
• 95274-54-7 3-[2-(1H-indol-3-yl)ethyl]-2-phenylquinazolin-4(3H)-one 
• 95274-43-4 N¹-(2-(carbomethoxyamino)benzoyl)tryptamine 
• 95274-55-8 3-<2-(3-indolyl)ethyl>-2-(trichloromethyl)-4-(3H)quinazolinone 
• 95274-41-2 N-(2-<(trichloroacetyl)amino>benzoyl)tryptamine 

Relevant articles and documents

Bicyclic 1,2,3-triazolium ionic liquids: Synthesis, characterization, and application to rutaecarpine synthesis

Starting with commercial reagents, bicyclic 1,2,3-triazolium ionic liquids [b-3C-tr][NTf2] (1) and [b-4C-tr][NTf2] (2) were synthesized in four steps with high overall isolated yields of 68% and 76%, respectively. Since the C-5 hydrogen is acidic, under basic condition ionic liquids 1 and 2 were readily methylated with methyl iodide to afford chemically stable ionic liquids 7 and 8 at room temperature (88% and 82%, respectively). Ionic liquid 1 was used as the ionic solvent to demonstrate its usefulness for the synthesis of rutaecarpine, a natural product.

Aryl substituted amide compounds and its preparation method, pharmaceutical composition containing the same and application thereof (by machine translation)

The invention relates to an aryl-substituted amide compound in the formula (I), a preparing method thereof, a medicine composition comprising the same, and application of the amide compound and the medicine composition to pharmacy, wherein Arl, L1, M1, M2, L2 and Ar2 are defined as in the text. The aryl-substituted amide compound can excite TRPV1 and nuclear receptors (LXRs, PPARs and RXR), adjust expression of cholesterol excretion gap-associated protein ABCA1/G1, SR-BI, adjust expression of inflammation gap-associated protein TNF-alpha and the like, and play roles in promoting excretion of cholesterol and lipid, reducing sugar, adjusting blood lipid, resisting inflammation and reducing blood pressure, and can be used for treating and/or preventing and/or relieving cardiovascular and cerebrovascular diseases, adjusting blood lipid, and resisting atherosclerosis, diabetes mellitus, inflammation, pain and hypertension.

Facile one-pot synthesis of quinazoline-2,4-dione derivatives and application to naturally occurring alkaloids from Zanthoxylum arborescens

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