332865-92-6

Upstream product

• 100-39-0 benzyl bromide 
• 332866-04-3 [4-¹³C]-(E)-((4-(benzyloxy)but-2-en-1-yl)oxy)(tert-butyl)dimethylsilane 

Downstream Products

• 1589494-14-3 [5-¹³C]-(3S,4R)-5-(benzyloxy)-3,4-dihydroxypentan-2-one 
• 1589494-08-5 [4-¹³C]-(E)-4-(benzyloxy)but-2-enal 
• 1589494-10-9 [5-¹³C]-(E)-5-(benzyloxy)but-3-en-2-ol 
• 1589494-12-1 [5-¹³C]-(E)-5-(benzyloxy)but-3-en-2-one 

Relevant academic research and scientific papers

Regioselective synthesis of 13C1-labeled 2-deoxyribonolactones

Syntheses of the five regioselectively 13C1-labeled 5-O-benzyl-2-deoxyribonolactones are described. 13C1-Labeled deoxyribonolactones were prepared by addition of KCN to epoxides 7 and subsequent lactonization of the resulting nitriles. Integration of the independent schemes leading to the five isotopomers of 9 results in an efficient and cost effective preparation of labeled mixtures of 13C mono-labeled deoxyribonolactones. These mixtures are the pivotal intermediates in the preparation of 'population labeled' 13C-labeled nucleoside phosphoramidites for solid-phase oligonucleotide synthesis.

Identification of isoafricanol and its terpene cyclase in Streptomyces violaceusniger using CLSA-NMR

The recently developed CLSA-NMR technique that is based on feeding experiments with 13C-labelled precursors was applied in the identification of isoafricanol as the main volatile terpene emitted by Streptomyces violaceusniger. The isoafricanol synthase of this organism is presented, together with a recent phylogenetic analysis of bacterial terpene cyclases. the Partner Organisations 2014.